Majía L A, Hodges R E, Arroyave G, Viteri F, Torún B
Am J Clin Nutr. 1977 Jul;30(7):1175-84. doi: 10.1093/ajcn/30.7.1175.
In order to investigate the role of vitamin A nutriture in the prevalence of anemia in Central America, a retrospective evaluation of the data of the six Institute of Nutrition of Central Americal and Panama/Office for International Research nutrition surveys of Central America and Panama has been made. Three groups of children; 1 to 4, 5 to 8, and 9 to 12 years old, living between 0 and 2,5000 feet above sea level were studeid. Several biochemical and dietary parameters related to anemia were corrleated with plasma levels of retinol. Children between the ages of 5 and 12 years showed a significant positive correlation between hemoglobin and plasma retinol. Children aged 1 to 4 years did not show a similar correlation. In children of all age groups there were positive correlations between plasma retinol and serum iron. Percent saturation of transferrin was also found to be lower when plasma retinol levels were low. Children with an adequate intake of iron, as classified by both dietary information and socioeconomic level, showed a significant positive correlation between plasma retinol levels and iron in their serum. In contrast, no correlation was found when dietary iron was low. In the light of these findings, a possible relationship between vitamin A deficiency and anemia is suggested.
为了研究维生素A营养状况在中美洲贫血患病率中的作用，对中美洲和巴拿马的六个中美洲营养研究所/国际研究办公室的中美洲和巴拿马营养调查数据进行了回顾性评估。研究了三组生活在海拔0至2500英尺之间的儿童，分别为1至4岁、5至8岁和9至12岁。将与贫血相关的几个生化和饮食参数与血浆视黄醇水平进行了关联分析。5至12岁的儿童血红蛋白与血浆视黄醇之间呈现出显著的正相关。1至4岁的儿童未表现出类似的相关性。在所有年龄组的儿童中，血浆视黄醇与血清铁之间均存在正相关。当血浆视黄醇水平较低时，转铁蛋白的饱和百分比也较低。根据饮食信息和社会经济水平分类，铁摄入量充足的儿童血浆视黄醇水平与血清铁之间呈现出显著的正相关。相比之下，当饮食中铁含量较低时未发现相关性。根据这些研究结果，提示维生素A缺乏与贫血之间可能存在关联。
