Rahman A S, Kimura M, Yokoi K, Itokawa Y
Department of Social Medicine, Graduate School of Medicine, Kyoto University, Japan.
Biol Trace Elem Res. 1995 Jul;49(1):75-84. doi: 10.1007/BF02789004.
To clarify the effect of vitamin A deficiency on iron, zinc, and copper status in different tissues, three groups of rats were fed two types of synthetic diets for 52 d. Group one, which was fed a vitamin A-deficient diet, showed severe signs of vitamin A deficiency. Groups two (fed restricted amount, pair-fed with group one), and three (fed diet ad libitum) were fed a control diet. After said period of feeding, iron, zinc, and copper were measured in different tissues. Significant changes observed when the groups were compared are summarized below: 1. Iron and copper in testes were increased significantly, whereas zinc was strikingly decreased in group one when compared with the other groups; 2. Copper (in lung and kidney) and iron (in the spleen) were increased significantly in group one compared with the other groups; 3. In the liver, iron, zinc, and copper were significantly different between group one and group two; 4. In muscle, iron was significantly higher in group one than group two; 5. In tibia and blood, iron levels (but not zinc and copper) in groups one and two were significantly higher than group three. These results suggest that vitamin A deficiency affects iron, zinc, and copper status in rats.
为阐明维生素A缺乏对不同组织中铁、锌和铜状态的影响，将三组大鼠喂食两种合成饲料，持续52天。第一组喂食维生素A缺乏饲料，表现出严重的维生素A缺乏症状。第二组（喂食限量饲料，与第一组配对喂食）和第三组（自由采食饲料）喂食对照饲料。在上述喂食期结束后，测量不同组织中的铁、锌和铜。比较各组时观察到的显著变化总结如下：1. 与其他组相比，第一组睾丸中的铁和铜显著增加，而锌显著减少；2. 与其他组相比，第一组肺和肾中的铜以及脾中的铁显著增加；3. 在肝脏中，第一组和第二组之间的铁、锌和铜存在显著差异；4. 在肌肉中，第一组的铁显著高于第二组；5. 在胫骨和血液中，第一组和第二组的铁水平（但锌和铜水平未出现此情况）显著高于第三组。这些结果表明，维生素A缺乏会影响大鼠体内铁、锌和铜的状态。
