血浆多巴胺β-羟化酶活性作为交感神经元功能指标的意义。
Significance of plasma dopamine beta-hydroxylase activity as an index of sympathetic neuronal function.
作者信息
Reid J L, Kopin I J
出版信息
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4392-4. doi: 10.1073/pnas.71.11.4392.
Abstract
Plasma norepinephrine and dopamine beta-hydroxylase (EC 1.14.17.1) activity were measured in rats. Adrenergic neuron blockade with bretylium for 4 hr and ganglion blockade with chlorisondamine for 72 hr lowered plasma norepinephrine. Neither treatment altered plasma dopamine beta-hydroxylase activity. Phenoxybenzamine for up to 48 hr markedly raised plasma norepinephrine and transiently lowered plasma dopamine beta-hydroxylase at 24 hr. Prolonged pharmacological modification of sympathetic nervous activity and plasma norepinephrine were not attended by parallel changes in circulating dopamine beta-hydroxylase activity. Plasma dopamine beta-hydroxylase activity does not appear to be a sensitive index of prolonged alterations in sympathetic neural activity. Norepinephrine in plasma, however, appears to reflect sensitively and accurately the rate of release of the neurotransmitter.
摘要
对大鼠的血浆去甲肾上腺素和多巴胺β-羟化酶（EC 1.14.17.1）活性进行了测定。用溴苄铵进行4小时的肾上腺素能神经元阻滞以及用氯异吲哚胺进行72小时的神经节阻滞均降低了血浆去甲肾上腺素水平。两种处理均未改变血浆多巴胺β-羟化酶活性。给予苯氧苄胺长达48小时可显著提高血浆去甲肾上腺素水平，并在24小时时短暂降低血浆多巴胺β-羟化酶活性。对交感神经活动和血浆去甲肾上腺素进行长时间的药理学调节，并未伴随着循环多巴胺β-羟化酶活性的平行变化。血浆多巴胺β-羟化酶活性似乎不是交感神经活动长期改变的敏感指标。然而，血浆中的去甲肾上腺素似乎能灵敏而准确地反映神经递质的释放速率。
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