Labauge R, Marty-Double C, Pages M, Boukobza M, Monstrey J
Rev Neurol (Paris). 1979;135(11):803-13.
While post-vaccinal encephalitis in children is unfortunately well known, its occurrence in adults is rather exceptional. The calendar of a poly vaccination situated so close to each other, most probably account for such an evolution. The case reported concerns a man of 27 years who presented 10 days after a polyvaccination (7 vaccines in 2 months) altered consciousness, epileptic fits, right hemiplegia, vegetative dysfunctions and meningeal status. Evolutionary clinical course led to death in 21 days. Neuropathological findings showed lymphocytic infiltrates in the cortex and basal ganglia, congestive aspect with petechial areas in the white matter and inflammatory meningeal infiltrates. All viral investigations both in the blood, brain and cerebrospinal fluid remained negative. Post-vaccinal encephalitis is reviewed. Vaccination cannot be condemned, but in case of polyvaccination lapse of time in between vaccines should be longer so as to prevent such exceptional evolution and fatal course.
虽然儿童接种疫苗后脑炎不幸广为人知，但在成人中发生却相当罕见。多种疫苗接种时间间隔如此之近，很可能是导致这种情况的原因。报告的病例是一名27岁男性，在进行多种疫苗接种（2个月内接种7种疫苗）10天后出现意识改变、癫痫发作、右侧偏瘫、植物神经功能障碍和脑膜症状。临床病程进展导致患者在21天后死亡。神经病理学检查结果显示，皮质和基底神经节有淋巴细胞浸润，白质有充血伴瘀点区，脑膜有炎性浸润。血液、大脑和脑脊液中的所有病毒检测均为阴性。本文对接种疫苗后脑炎进行了综述。不能谴责疫苗接种，但在进行多种疫苗接种时，疫苗之间的间隔时间应更长，以防止这种罕见情况的发生和致命结局。
