人血清对b型流感嗜血杆菌的活性。
Human serum activities against Hemophilus influenzae, type b.
作者信息
Anderson P, Johnston R B, Smith D H
出版信息
J Clin Invest. 1972 Jan;51(1):31-8. doi: 10.1172/JCI106793.
Abstract
Humoral immunity to Hemophilus influenzae, type b was studied in normal human adults by means of assays for serum bactericidal and opsonizing activities against the organism and for passive hemagglutinating activity using erythrocytes sensitized with polyribophosphate, the type-specific capsular antigen. Hemagglutinating activity was detectable in about 60% of the 114 sera tested. Serum bactericidal and opsonizing activities were found in all sera tested; the levels in some sera, however, were quite low. The antibacterial activities were due not only to antibodies directed against the polyribophosphate capsule but also to antibodies that appear to be directed against somatic antigens. Type b strains differed in their susceptibility to the antisomatic antibodies of particular sera but were uniformly sensitive to anticapsular antibody.
摘要
通过检测血清针对该细菌的杀菌和调理活性以及使用用多聚核糖磷酸（b型特异性荚膜抗原）致敏的红细胞进行被动血凝活性检测，研究了正常成年人体内针对b型流感嗜血杆菌的体液免疫。在所检测的114份血清中，约60%可检测到血凝活性。在所有检测的血清中均发现了血清杀菌和调理活性；然而，一些血清中的水平相当低。抗菌活性不仅归因于针对多聚核糖磷酸荚膜的抗体，还归因于似乎针对体细胞抗原的抗体。b型菌株对特定血清的抗体细胞抗体的敏感性不同，但对抗荚膜抗体均敏感。
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