Dahlberg-Lagergård T
Acta Pathol Microbiol Immunol Scand C. 1982 Aug;90(4):209-16. doi: 10.1111/j.1699-0463.1982.tb01440.x.
Three components of Haemophilus influenzae (capsular polysaccharide, lipopolysaccharide and proteins of the outer membrane) were studied concerning their possible rôle as target antigens for bactericidal and opsonizing antibodies. In rabbit antisera against capsulated H. influenzae the bactericidal antibodies were mainly directed against the capsular polysaccharide but also, to a smaller extent, against the outer membrane antigens. Using a non-capsulated mutant of H. influenzae type b it was demonstrated that both the lipopolysaccharide and the proteins of the outer membrane are target antigens for bactericidal antibodies. In antisera against whole bacteria antibodies against the lipopolysaccharide and the outer membrane, proteins were in equal concentrations, while in antisera against the outer membrane a greater proportion of the bactericidal antibodies were directed against the lipopolysaccharide. Some of the outer membrane target proteins for bactericidal antibodies were common to various serotypes of H. influenzae. The capsular polysaccharide as well as the lipopolysaccharide and the proteins of the outer membrane constituted target antigens also for opsonizing antibodies to capsulated H. influenzae type b.
对流感嗜血杆菌的三种成分（荚膜多糖、脂多糖和外膜蛋白）进行了研究，探讨它们作为杀菌抗体和调理素抗体的靶抗原的可能作用。在针对有荚膜流感嗜血杆菌的兔抗血清中，杀菌抗体主要针对荚膜多糖，但在较小程度上也针对外膜抗原。利用b型流感嗜血杆菌的无荚膜突变体证明，脂多糖和外膜蛋白都是杀菌抗体的靶抗原。在针对全菌的抗血清中，抗脂多糖和外膜蛋白的抗体浓度相等，而在针对外膜的抗血清中，更大比例的杀菌抗体针对脂多糖。杀菌抗体的一些外膜靶蛋白在流感嗜血杆菌的不同血清型中是共有的。荚膜多糖以及脂多糖和外膜蛋白也是针对b型有荚膜流感嗜血杆菌调理素抗体的靶抗原。
