Comstock G W, Baum C, Snider D E
Am Rev Respir Dis. 1979 May;119(5):827-30. doi: 10.1164/arrd.1979.119.5.827.
As a result of numerous trials, isoniazid prophylaxis was shown to be effective in preventing tuberculosis in many different populations and under a variety of conditions. However, the duration of the protective effect has been of some concern. In a previous report, the protective effect of isoniazid prophylaxis among Alaskan Eskimos was shown to persist through the fifteenth year after its administration. In this final report, the protective effect is shown to persist for more than 19 years. The magnitude of the effect is related to the amount of isoniazid taken. The results of the study are consistent with the hypothesis that the decrease in risk of tuberculosis produced by isoniazid preventive therapy is lifelong.
经过大量试验，异烟肼预防疗法在许多不同人群和各种条件下均被证明对预防结核病有效。然而，其保护作用的持续时间一直备受关注。在之前的一份报告中，阿拉斯加爱斯基摩人中异烟肼预防疗法的保护作用在给药后的第十五年仍持续存在。在这份最终报告中，保护作用被证明持续了超过19年。该作用的程度与服用的异烟肼量有关。研究结果与异烟肼预防性治疗导致结核病风险降低是终身的这一假设一致。
