微生物在精神活性物质生物转化中的作用及其法医学意义：一项重要的跨学科综述。
The role of microorganisms in the biotransformation of psychoactive substances and its forensic relevance: a critical interdisciplinary review.
作者信息
de Campos Eduardo G, de Almeida Otávio G G, De Martinis Elaine C P
机构信息
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Department of Chemistry and Fermentation Sciences, Appalachian State University, Boone, NC, USA.
出版信息
Forensic Sci Res. 2023 Sep 4;8(3):173-184. doi: 10.1093/fsr/owad025. eCollection 2023 Sep.
UNLABELLED
Microorganisms are widespread on the planet being able to adapt, persist, and grow in diverse environments, either rich in nutrient sources or under harsh conditions. The comprehension of the interaction between microorganisms and drugs is relevant for forensic toxicology and forensic chemistry, elucidating potential pathways of microbial metabolism and their implications. Considering the described scenario, this paper aims to provide a comprehensive and critical review of the state of the art of interactions amongst microorganisms and common drugs of abuse. Additionally, other drugs of forensic interest are briefly discussed. This paper outlines the importance of this area of investigation, covering the intersections between forensic microbiology, forensic chemistry, and forensic toxicology applied to drugs of abuse, and it also highlights research potentialities.
KEY POINTS
Microorganisms are widespread on the planet and grow in a myriad of environments.Microorganisms can often be found in matrices of forensic interest.Drugs can be metabolized or produced (e.g. ethanol) by microorganisms.
未标注
微生物在地球上广泛存在，能够在各种环境中适应、存活和生长，这些环境要么富含营养源，要么条件恶劣。理解微生物与药物之间的相互作用对于法医毒理学和法医化学至关重要，有助于阐明微生物代谢的潜在途径及其影响。考虑到上述情况，本文旨在对微生物与常见滥用药物之间相互作用的现有技术水平进行全面而批判性的综述。此外，还简要讨论了其他具有法医意义的药物。本文概述了这一研究领域的重要性，涵盖了应用于滥用药物的法医微生物学、法医化学和法医毒理学之间的交叉点，并突出了研究潜力。
关键点
微生物在地球上广泛存在，在无数环境中生长。
微生物常常存在于具有法医意义的基质中。
药物可被微生物代谢或产生（如乙醇）。
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