刺孢小克银汉霉对联苯进行羟基化的机制。
Mechanism of hydroxylation of biphenyl by Cunninghamella echinulata.
作者信息
Smith R V, Davis P J, Clark A M, Prasatik S K
出版信息
Biochem J. 1981 Apr 15;196(1):369-71. doi: 10.1042/bj1960369.
Abstract
The hydroxylation of [U-2H]biphenyl and [2,2',3,3',5,5',6,6'-2H]biphenyl by Cunninghamella echinulata A.T.C.C. 9244 has been studied. G.l.c.-mass-spectrometry analyses indicate the lack of an isotope effect during the hydroxylation of the perdeuterated substrate. Both g.l.c.-mass spectrometry and 1H n.m.r. were used to definitively demonstrate the presence of a 1,2-hydride-shift during the microbiological hydroxylation of [2,2',3,3',5,5',6,6'-2H]biphenyl.
摘要
已对刺孢小克银汉霉A.T.C.C. 9244对[U-2H]联苯和[2,2',3,3',5,5',6,6'-2H]联苯的羟基化作用进行了研究。气相色谱-质谱分析表明，在全氘代底物的羟基化过程中不存在同位素效应。气相色谱-质谱分析和1H核磁共振均被用于明确证明在[2,2',3,3',5,5',6,6'-2H]联苯的微生物羟基化过程中存在1,2-氢转移。
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