Thomsen K, Rothenborg H W
Arch Dermatol. 1979 Jul;115(7):851-2.
Ten patients with pyoderma gangrenosum, seven female and three male, 25 to 94 years old, mainly with multiple lesions, have been treated with clofazimine, 100 mg three times daily. Associated disease was registered in three patients: diabetes mellitus, a previous adenocarcinoma of the colon treated by hemicolectomy, and pustulosis palmoplantaris. In a further patient, M-component was found in the serum. In seven cases the lesions were completely healed by two to five months of therapy, and in three cases the ulcers healed partially. Side effects were redness of the skin in seven cases and dryness of the skin in two patients. No hematological side effects occurred. The working mechanism is still obscure.
10例坏疽性脓皮病患者，7例女性，3例男性，年龄25至94岁，主要为多发损害，接受氯法齐明治疗，每日3次，每次100mg。3例患者伴有相关疾病：糖尿病、曾行半结肠切除术治疗的结肠腺癌、掌跖脓疱病。另有1例患者血清中发现M蛋白成分。7例患者经2至5个月治疗后皮损完全愈合，3例患者溃疡部分愈合。副作用包括7例皮肤发红和2例皮肤干燥。未出现血液学副作用。作用机制仍不清楚。
