配体诱导的淋巴细胞膜大分子运动。3. 抗Ig-表面Ig复合物的形成与命运和细胞代谢之间的关系。
Ligand-induced movement of lymphocyte membrane macromolecules. 3. Relationship between the formation and fate of anti-Ig-surface Ig complexes and cell metabolism.
作者信息
Unanue E R, Karnovsky M J, Engers H D
出版信息
J Exp Med. 1973 Mar 1;137(3):675-89. doi: 10.1084/jem.137.3.675.
Abstract
Spleen lymphocytes were studied for the movement and interiorization of complexes of anti-Ig-surface Ig. The movement of the complex into a small, compact zone of the cell membrane (forming a cap) was inhibited by drugs that inhibited glycolysis and oxidative phosphorylation, but not by drugs that affected protein synthesis. Dead lymphocytes did not form caps. Freeze-etching techniques revealed that inhibited lymphocytes showed formation of multiple small complexes over the entire cell surface. Inhibitors of glycolysis and of oxidative phosphorylation also inhibited the interiorization and catabolism of radioiodinated anti-Ig. We hypothesize that cross-linking of all the surface Ig triggers the membrane movements that are required to pull the lattice into one zone of the cell.
摘要
研究了脾淋巴细胞中抗Ig-表面Ig复合物的移动和内化。复合物向细胞膜的一个小而紧密的区域（形成帽）的移动受到抑制糖酵解和氧化磷酸化的药物的抑制，但不受影响蛋白质合成的药物的抑制。死亡的淋巴细胞不形成帽。冷冻蚀刻技术显示，受抑制的淋巴细胞在整个细胞表面形成多个小复合物。糖酵解和氧化磷酸化的抑制剂也抑制放射性碘化抗Ig的内化和分解代谢。我们推测，所有表面Ig的交联触发了将晶格拉到细胞的一个区域所需的膜运动。
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