遗传性无反应小鼠淋巴细胞的抗原结合与帽形成
Antigen binding and capping by lymphocytes of genetic nonresponder mice.
作者信息
Dunham E K, Unanue E R, Benacerraf B
出版信息
J Exp Med. 1972 Aug 1;136(2):403-8. doi: 10.1084/jem.136.2.403.
Abstract
Radioautographic study of the binding of GAT-(125)I to spleen cells of genetic responder and nonresponder mice demonstrates that among mice not injected with antigen all strains have approximately the same number of antigen-binding cells; after injection with antigen the number of antigen-binding cells increases in responders but not in nonresponders. Nonresponders are shown to make antibody after injection with GAT complexed with an immunogenic carrier, demonstrating the presence of potentially functional B cells in responders and nonresponders alike. When incubated in the warm, antigen-binding cells of both responders and nonresponders concentrate antigen at one pole of the cell, forming caps.
摘要
用放射自显影法研究（125）I标记的谷氨酸转氨酶（GAT）与遗传反应型和无反应型小鼠脾细胞的结合情况，结果表明，在未注射抗原的小鼠中，所有品系的抗原结合细胞数量大致相同；注射抗原后，反应型小鼠的抗原结合细胞数量增加，而无反应型小鼠则没有增加。研究显示，给无反应型小鼠注射与免疫原性载体结合的GAT后，它们会产生抗体，这表明反应型和无反应型小鼠中都存在具有潜在功能的B细胞。当在温暖环境中孵育时，反应型和无反应型小鼠的抗原结合细胞都会将抗原集中在细胞的一极，形成帽状结构。
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引用本文的文献
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