Grayson S, Berry S J
Science. 1973 Jun 8;180(4090):1071-2. doi: 10.1126/science.180.4090.1071.
Synthesis of a specific secretory protein was followed in the presence of actinomycin D and cordycepin (3'-deoxyadenosine). The apparent half-life of the messenger RNA for this protein is significantly longer in the presence of actinomycin D than in the presence of cordycepin. These results suggest that actinomycin D studies of half-life in specialized cells may be inaccurate.
在放线菌素D和虫草素（3'-脱氧腺苷）存在的情况下，追踪一种特定分泌蛋白的合成过程。在放线菌素D存在时，这种蛋白质信使RNA的表观半衰期明显长于在虫草素存在时的表观半衰期。这些结果表明，在特化细胞中用放线菌素D研究半衰期可能不准确。
