Naritomi H, Meyer J S, Sakai F, Yamaguchi F, Shaw T
Arch Neurol. 1979 Jul;36(7):410-6. doi: 10.1001/archneur.1979.00500430040005.
Regional cerebral blood flow (rCBF) was measured by 133Xe inhalation in 46 normal volunteers, aged 21 to 63 years, and 14 neurologically asymptomatic subjects above age 40 with risk factors for atherothrombotic stroke, including hypertension, diabetes mellitus, and hyperlipidemia. In normal volunteers, there was diffuse and progresive reduction of gray matter flow and weight as well as increases of cerebrovascular resistance (CVR) with advancing age. Reduction of gray matter flow with advancing age appears to be attributed in part to neuronal atrophy and in part to cerebral arteriosclerosis. Regional increases of CVR and reduction of gray matter flow with advancing age were most evident in the middle cerebral arterial (MCA) distribution and were enhanced by the association of risk factors. Development of cerebral arteriosclerosis with age and/or risk factors appears to be most evident in MCA distribution.
对46名年龄在21至63岁的正常志愿者以及14名年龄在40岁以上、有动脉粥样硬化性血栓形成性中风危险因素（包括高血压、糖尿病和高脂血症）的神经无症状受试者，通过吸入133Xe测量局部脑血流量（rCBF）。在正常志愿者中，随着年龄增长，灰质血流量和重量呈弥漫性进行性减少，脑血管阻力（CVR）增加。随着年龄增长，灰质血流量减少似乎部分归因于神经元萎缩，部分归因于脑动脉硬化。随着年龄增长，CVR局部增加和灰质血流量减少在大脑中动脉（MCA）分布区最为明显，且危险因素并存时会加剧这种情况。随着年龄增长和/或存在危险因素时，脑动脉硬化的发展在MCA分布区似乎最为明显。
