Lewis C M, Pegrum G D
Immunology. 1973 Oct;25(4):697-701.
When nuclei from the lymphocytes of mice immunized with rabbit erythrocytes are injected into unprimed animals the number of cells forming antibody to rabbit erythrocytes increases to a level approaching that of the immunized donor animals. The specificity of the response induced by nuclei is equally as good as that induced by native antigen. When T' and B' mice are immunized with rabbit erythrocytes a poor response is observed but when the nuclei from primed T' animals are used to immunize B' mice the number of antibody-producing cells is very much increased. In view of current theories about cellular co-operation it is pointed out that this co-operative effect of `T' lymphocyte nuclei is independent of both cell membrane and additional antigen.
将用兔红细胞免疫的小鼠淋巴细胞的细胞核注射到未致敏的动物体内时，形成抗兔红细胞抗体的细胞数量增加到接近免疫供体动物的水平。由细胞核诱导的反应特异性与天然抗原诱导的一样好。当用兔红细胞免疫“T”和“B”小鼠时，观察到反应较差，但当用致敏“T”动物的细胞核免疫“B”小鼠时，产生抗体的细胞数量大大增加。鉴于当前关于细胞合作的理论，有人指出，“T”淋巴细胞细胞核的这种合作效应与细胞膜和额外抗原均无关。
