Diamantstein T, Rühl H, Vogt W, Bochert G
Immunology. 1973 Oct;25(4):743-7.
Dextran sulphate (DS) stimulates [H]TdR incorporation in spleen cells of various strains of mice including athymic nude mice. In spleen cells of normal mice an additive effect of DS on the PHA-response was detected. The results suggest that DS is a B-cell mitogen. It seems that the mitogenic activity of polyanions may be related to their effects on antibody formation.
硫酸葡聚糖(DS)可刺激包括无胸腺裸鼠在内的多种品系小鼠脾细胞中[H]TdR的掺入。在正常小鼠的脾细胞中,检测到DS对PHA反应有相加作用。结果表明,DS是一种B细胞有丝分裂原。多聚阴离子的促有丝分裂活性似乎与其对抗体形成的影响有关。