混合淋巴细胞反应中的刺激-反应
Stimulus-response in the mixed lymphocyte reaction.
作者信息
Harrison M R, Paul W E
出版信息
J Exp Med. 1973 Dec 1;138(6):1602-7. doi: 10.1084/jem.138.6.1602.
Abstract
Mixed lymphocyte reactions occur when mouse spleen cell populations depleted of thymus-derived (T) lymphocytes are cultured with allogeneic target cells inactivated by mitomycin C or X irradiation, and when F(1) hybrid responder cells are cultured with inactivated parental target cells. These responses might be interpreted as indicating that T lymphocytes are not required for responsiveness and that F(1) lymphocytes recognize parental alloantigens. Data reported here indicate that the more likely explanation for these surprising results is that inactivated target cells recognize the "responding" cells and this recognition leads to the response observed.
摘要
当去除胸腺来源（T）淋巴细胞的小鼠脾细胞群体与经丝裂霉素C或X射线照射而失活的同种异体靶细胞一起培养时，以及当F（1）杂种反应细胞与失活的亲代靶细胞一起培养时，会发生混合淋巴细胞反应。这些反应可能被解释为表明反应性不需要T淋巴细胞，并且F（1）淋巴细胞识别亲代同种异体抗原。此处报告的数据表明，对这些惊人结果更可能的解释是失活的靶细胞识别“反应性”细胞，并且这种识别导致观察到的反应。
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