I区基因在T淋巴细胞和B淋巴细胞上表达。混合淋巴细胞反应（MLR）的研究。
I-region genes are expressed on T and B lymphocytes. Studies of the mixed lymphocyte reaction (MLR).
作者信息
Lonai P, McDevitt H O
出版信息
J Exp Med. 1974 Nov 1;140(5):1317-23. doi: 10.1084/jem.140.5.1317.
Abstract
Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region, both T and B cells stimulated in the MLR. This suggests that the region codes for both T- and B-cell surface structures. However, if the difference was restricted to one I subregion (I-C), only T cells stimulated. This finding suggests that some of the I-region genes may be expressed either in T or in B cells.
摘要
在H-2复合体中不同区域存在差异的小鼠品系之间进行单向混合淋巴细胞反应（MLR）。胸腺细胞、纯化的淋巴结T细胞和B细胞用作刺激细胞。在所研究的五组组合中的三组中，仅在I区域内存在差异，T细胞和B细胞在MLR中均受到刺激。这表明该区域编码T细胞和B细胞的表面结构。然而，如果差异仅限于一个I亚区域（I-C），则只有T细胞受到刺激。这一发现表明，一些I区域基因可能在T细胞或B细胞中表达。
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