心脏线粒体Ca2+外流的调节。
Modulation of Ca2+ efflux from heart mitochondria.
作者信息
Harris E J
出版信息
Biochem J. 1979 Mar 15;178(3):673-80. doi: 10.1042/bj1780673.
Abstract
The efflux of Ca2+ from rat heart mitochondria has been examined by using Ruthenium Red to inhibit active uptake after predetermined loadings with Ca2+. The efflux is proportional to the internal Ca2+ load; it is increased by Na+ applied when the mitochondria are respiring and this effect is inhibited by oligomycin. The efflux of Ca2+ is diminished by ATP and by ADP, with the latter the more effective. Both active uptake and efflux of Ca2+ are slowed by bongkrekic acid; this action has a time lag. The lower efflux found with the nucleotides and with bongkrekic acid seems to correspond to the more condensed state seen in the electron microscope when these agents are applied [Stoner & Sirak (1973) J. Cell Biol. 56, 51-64, 65-73]. The results are discussed in relation to the less-permeable state being contingent upon nucleotide binding to the membrane.
摘要
在用钌红抑制预先加载钙离子后的主动摄取后，对大鼠心脏线粒体中钙离子的外流进行了检测。外流与内部钙离子负荷成正比；当线粒体进行呼吸时，钠离子的施加会增加外流，而这种效应会被寡霉素抑制。ATP和ADP会减少钙离子的外流，后者更有效。钙离子的主动摄取和外流都被邦克里尔酸减慢；这种作用有一个时间滞后。在用核苷酸和邦克里尔酸时发现的较低外流似乎与在应用这些试剂时电子显微镜中看到的更浓缩状态相对应[斯托纳和西拉克（1973年）《细胞生物学杂志》56卷，51 - 64页，65 - 73页]。结果结合核苷酸与膜结合后通透性较低的状态进行了讨论。
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本文引用的文献
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Effect of bongkrekic acid on the adenine nucleotide carrier in mitochondria: tightening of adenine nucleotide binding and differentiation between inner and outer sites.膨压素对线粒体中腺嘌呤核苷酸载体的作用：腺嘌呤核苷酸结合的紧密化及内外位点的区分
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