• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种用于测定狂犬病中和抗体的快速可重复检测方法。

A rapid reproducible test for determining rabies neutralizing antibody.

作者信息

Smith J S, Yager P A, Baer G M

出版信息

Bull World Health Organ. 1973 May;48(5):535-41.

PMID:4544144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2482941/
Abstract

Rabies neutralizing antibody levels in human and animal sera were tested by a rapid fluorescent focus inhibition technique, in which BHK-21 cells were infected with tissue-culture-adapted rabiesvirus. The results, obtained in 24 hours, were comparable with those of the standard mouse neutralization test.

摘要

采用快速荧光灶抑制技术检测人和动物血清中的狂犬病中和抗体水平，该技术中，用适应组织培养的狂犬病病毒感染BHK - 21细胞。24小时内获得的结果与标准小鼠中和试验的结果相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edf7/2482941/40e4ff0b5713/bullwho00178-0029-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edf7/2482941/e2214ce8999e/bullwho00178-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edf7/2482941/6dff1150eb2b/bullwho00178-0029-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edf7/2482941/40e4ff0b5713/bullwho00178-0029-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edf7/2482941/e2214ce8999e/bullwho00178-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edf7/2482941/6dff1150eb2b/bullwho00178-0029-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edf7/2482941/40e4ff0b5713/bullwho00178-0029-c.jpg

相似文献

1
A rapid reproducible test for determining rabies neutralizing antibody.一种用于测定狂犬病中和抗体的快速可重复检测方法。
Bull World Health Organ. 1973 May;48(5):535-41.
2
Rabies antibody determination by immunofluorescence in tissue culture.通过组织培养中的免疫荧光法测定狂犬病抗体
Infect Immun. 1972 Jun;5(6):902-4. doi: 10.1128/iai.5.6.902-904.1972.
3
Development and evaluation of a rapid neutralizing antibody test for rabies.狂犬病快速中和抗体检测方法的开发与评估
J Virol Methods. 2009 Oct;161(1):58-62. doi: 10.1016/j.jviromet.2009.05.018. Epub 2009 May 27.
4
A rapid tissue culture test for determining rabies neutralizing antibody.一种用于检测狂犬病中和抗体的快速组织培养试验。
Monogr Ser World Health Organ. 1973(23):354-7.
5
Comparison of visual microscopic and computer-automated fluorescence detection of rabies virus neutralizing antibodies.狂犬病病毒中和抗体的视觉显微镜检测与计算机自动荧光检测的比较。
J Vet Diagn Invest. 1999 Jul;11(4):330-3. doi: 10.1177/104063879901100406.
6
Evaluation of an improved rapid neutralizing antibody detection test (RAPINA) for qualitative and semiquantitative detection of rabies neutralizing antibody in humans and dogs.评估改良快速中和抗体检测试验（RAPINA）在定性和半定量检测人类和犬类狂犬病中和抗体中的应用。
Vaccine. 2012 Jun 6;30(26):3891-6. doi: 10.1016/j.vaccine.2012.04.003. Epub 2012 Apr 16.
7
Rabies neutralizing antibodies determination by the modified counterimmunoelectrophoresis test and the rapid fluorescent focus inhibition test.采用改良对流免疫电泳试验和快速荧光灶抑制试验测定狂犬病中和抗体。
Zentralbl Bakteriol Mikrobiol Hyg A. 1983 Nov;256(1):1-6.
8
Characterization of brain-associated rabies neutralizing substance.脑相关狂犬病中和物质的特性分析
J Infect Dis. 1974 Apr;129(4):456-60. doi: 10.1093/infdis/129.4.456.
9
Microneutralization test for rabies virus based on an enzyme immunoassay.基于酶免疫测定法的狂犬病病毒微量中和试验。
J Clin Microbiol. 1987 Dec;25(12):2440-2. doi: 10.1128/jcm.25.12.2440-2442.1987.
10
[The establishment of a rapid fluorescent focus inhibition test for testing rabies virus neutralizing antibody].[建立用于检测狂犬病病毒中和抗体的快速荧光灶抑制试验]
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Apr;31(4):438-41.

引用本文的文献

1
The Challenge of Lyssavirus Infections in Domestic and Other Animals: A Mix of Virological Confusion, Consternation, Chagrin, and Curiosity.家猫和其他动物感染狂犬病病毒的挑战：病毒学上的困惑、惊愕、懊恼与好奇交织。
Pathogens. 2025 Jun 13;14(6):586. doi: 10.3390/pathogens14060586.
2
Long-term persistence and boostability of immune responses following different rabies pre-exposure prophylaxis priming schedules of a purified chick embryo cell rabies vaccine administered alone or concomitantly with a Japanese encephalitis vaccine.单独接种或与日本脑炎疫苗同时接种纯化鸡胚细胞狂犬病疫苗的不同暴露前预防免疫程序后免疫反应的长期持续性和增强能力。
PLoS Negl Trop Dis. 2025 May 27;19(5):e0013118. doi: 10.1371/journal.pntd.0013118. eCollection 2025 May.
3

本文引用的文献

1
Propagation of Rabies Virus in Pig Kidney Cell Culture.狂犬病病毒在猪肾细胞培养物中的增殖
Can Vet J. 1964 Apr;5(4):84-7.
2
Polyoma transformation of hamster cell clones--an investigation of genetic factors affecting cell competence.仓鼠细胞克隆的多瘤病毒转化——对影响细胞感受态的遗传因素的研究
Virology. 1962 Feb;16:147-51. doi: 10.1016/0042-6822(62)90290-8.
3
A simple chromatographic method for preparation of gamma globulin.一种制备γ球蛋白的简易色谱法。
Development and validation of a blocking ELISA for measurement of rabies virus neutralizing antibody.一种用于检测狂犬病病毒中和抗体的阻断酶联免疫吸附测定法的开发与验证
J Clin Microbiol. 2025 Jun 11;63(6):e0204924. doi: 10.1128/jcm.02049-24. Epub 2025 May 14.
4
Assessing anti-rabies vaccine response in humans: A rapid and high-throughput adaptable, pseudovirus-based neutralization assay as an alternative to rapid fluorescent focus inhibition test (RFFIT).评估人类抗狂犬病疫苗反应：一种快速且高通量适用的基于假病毒的中和试验，作为快速荧光灶抑制试验（RFFIT）的替代方法。
PLoS Negl Trop Dis. 2025 Apr 10;19(4):e0013010. doi: 10.1371/journal.pntd.0013010. eCollection 2025 Apr.
5
Safety and immunogenicity of an optimized self-replicating RNA platform for low dose or single dose vaccine applications: a randomized, open label Phase I study in healthy volunteers.用于低剂量或单剂量疫苗应用的优化自我复制RNA平台的安全性和免疫原性：一项在健康志愿者中进行的随机、开放标签的I期研究。
Nat Commun. 2025 Jan 7;16(1):456. doi: 10.1038/s41467-025-55843-9.
6
Rabies Vaccination for Sheep and Goats: Influence of Booster on Persistence of Antibody Response.绵羊和山羊的狂犬病疫苗接种：加强免疫对抗体反应持久性的影响。
Vet Sci. 2024 Oct 13;11(10):502. doi: 10.3390/vetsci11100502.
7
Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease.基于灭活狂犬病的拉沙热病毒候选疫苗LASSARAB可保护非人灵长类动物免受致命疾病侵害。
NPJ Vaccines. 2024 Aug 9;9(1):143. doi: 10.1038/s41541-024-00930-z.
8
Construction of Vero cell-adapted rabies vaccine strain by five amino acid substitutions in HEP-Flury strain.构建通过在HEP-Flury 株中五个氨基酸替换适应 Vero 细胞的狂犬病疫苗株。
Sci Rep. 2024 May 31;14(1):12559. doi: 10.1038/s41598-024-63337-9.
9
Immunogenicity and Safety of a Purified Vero Rabies Vaccine-Serum Free, Compared With 2 Licensed Vaccines, in a Simulated Rabies Post-Exposure Regimen in Healthy Adults in France: A Randomized, Controlled, Phase 3 Trial.在法国健康成年人的模拟狂犬病暴露后治疗方案中，一种纯化的无血清Vero狂犬病疫苗与两种已获许可疫苗相比的免疫原性和安全性：一项随机、对照、3期试验。
Clin Infect Dis. 2024 Jun 14;78(6):1748-1756. doi: 10.1093/cid/ciae137.
10
Persistence of Anti-Rabies Antibody Response in Horses Following Vaccination.马匹接种疫苗后抗狂犬病抗体反应的持久性。
Pathogens. 2024 Jan 28;13(2):125. doi: 10.3390/pathogens13020125.
Proc Soc Exp Biol Med. 1960 Jan;103:250-2. doi: 10.3181/00379727-103-25476.
4
Demonstration of rabies virus in tissue culture with fluorescent antibody technique.用荧光抗体技术在组织培养中显示狂犬病病毒。
Bull World Health Organ. 1960;22(3-4):434-5.
5
A RAPID QUANTITATIVE IN VITRO SERUM NEUTRALIZATION TEST FOR RABIES ANTIBODY.一种快速定量的狂犬病抗体体外血清中和试验。
Can Vet J. 1965 Aug;6(8):187-93.
6
STUDIES ON THE LOW EGG PASSAGE FLURY STRAIN OF MODIFIED LIVE RABIES VIRUS PRODUCED IN EMBRYONATING CHICKEN EGGS AND TISSUE CULTURE.鸡胚和组织培养中生产的改良活狂犬病病毒低传代弗吕里毒株的研究
Am J Vet Res. 1964 May;25:756-63.
7
ANTI-RABIES VACCINE OF TISSUE CULTURE ORIGIN.组织培养源狂犬病疫苗
J Immunol. 1963 Sep;91:362-8.
8
MECHANISM OF THE CYTOPATHIC EFFECT OF RABIES VIRUS IN TISSUE CULTURE.狂犬病病毒在组织培养中的细胞病变效应机制
Virology. 1963 Sep;21:128-31. doi: 10.1016/0042-6822(63)90312-x.
9
[Multiplication of rabies street virus on mouse ependymoma in tissue culture; cytolytic effect].[狂犬病街毒株在组织培养中的小鼠室管膜瘤上的增殖；细胞溶解作用]
Ann Inst Pasteur (Paris). 1959 Jan;96(1):72-8.
10
Superiority of fluorescein isothiocyanate (Riggs) for fluorescent-antibody technic with a modification of its application.异硫氰酸荧光素（里格斯）在荧光抗体技术中的优势及其应用的改进
Proc Soc Exp Biol Med. 1958 Aug-Sep;98(4):898-900. doi: 10.3181/00379727-98-24222.