Holmes E W, Blondet P
Arthritis Rheum. 1979 Jul;22(7):737-9. doi: 10.1002/art.1780220707.
Fractional excretion of uric acid (Curate/Ccreat X 100) was determined in 1 4-year-old analbuminemic child and an age-matched control. Fractional excretion of urate was 19% in the analbuminemic child and 24% in the control subject. These values are within the range reported for normal children of this age. We conclude from this study that urate binding to serum albumin is not an important determinant of the renal clearance of uric acid, and by inference there is no significant binding of urate to serum albumin in vivo.
在一名4岁的无白蛋白血症儿童和一名年龄匹配的对照者中测定了尿酸排泄分数（尿酸清除率/肌酐清除率×100）。无白蛋白血症儿童的尿酸排泄分数为19%，对照者为24%。这些值在该年龄正常儿童报道的范围内。我们从这项研究得出结论，尿酸与血清白蛋白的结合不是尿酸肾清除率的重要决定因素，由此推断，尿酸在体内与血清白蛋白无显著结合。
