Boyle J A, Campbell S, Duncan A M, Greig W R, Buchanan W W
J Clin Pathol. 1966 Sep;19(5):501-3. doi: 10.1136/jcp.19.5.501.
Serum uric acid estimations were performed in 106 healthy pregnant women during early, middle, and late pregnancy, using an automated colorimetric method. The mean serum uric acid level was significantly lower during early and middle pregnancy than that of 64 age-matched female controls. The serum uric acid level was not significantly different in late pregnancy from the control group. Studies of the daily urinary urate excretion in 31 pregnant women showed normal urinary urate excretion in early pregnancy and enhanced renal loss of urate in middle and late pregnancy. It appears that the renal clearance of urate in pregnancy is high, especially in the middle period when the serum level is low in spite of the increased production of uric acid by the foetus.
采用自动比色法对106名健康孕妇在妊娠早、中、晚期进行血清尿酸测定。妊娠早期和中期的平均血清尿酸水平显著低于64名年龄匹配的女性对照组。妊娠晚期血清尿酸水平与对照组无显著差异。对31名孕妇每日尿尿酸排泄的研究表明，妊娠早期尿尿酸排泄正常，妊娠中晚期尿酸肾排泄增加。看来妊娠期间尿酸的肾清除率很高，尤其是在中期，尽管胎儿尿酸生成增加，但血清水平却很低。
