McMichael A J, Williamson A R
J Exp Med. 1974 May 1;139(5):1361-7. doi: 10.1084/jem.139.5.1361.
A single clone of B cells producing anti-DNP antibody recognizable by the isoelectric-focusing spectrum has been used, in a double transfer system, to study clonal memory. Trasnsferable B memory develops between 4 and 7 days after the first transfer with antigen. B-memory cells thus proliferate before or concomitantly with antibody-forming cells.
利用一株产生可通过等电聚焦光谱识别的抗二硝基苯酚(DNP)抗体的B细胞克隆,在双重转移系统中研究克隆记忆。可转移的B记忆在首次用抗原转移后的4至7天内形成。因此,B记忆细胞在抗体形成细胞之前或同时增殖。