McDonald V, Phillips R S
Immunology. 1978 May;34(5):821-30.
Thymectomized NIH and C57BL mice were more susceptible to Plasmodium chabaudi than controls, indicating a role for T cells in acquired immunity to the parasite. Enriched populations of T and B cells were prepared from the spleens of immune mice using nylon-wool columns, and were adoptively transferred to syngeneic non-irradiated mice or mice irradiated with 600 or 800 rad. Some immunity could usually be transferred with immune T, B and glass-wool (g.w.) filtered spleen cell populations. In the heavily irradiated mice g.w. filtered immune spleen cells gave the best protection and the immune T cells the least. Preliminary attempts to show synergistic activity between immune T and B cells in irradiated mice were not successful.
胸腺切除的NIH和C57BL小鼠比对照小鼠更易感染查巴迪疟原虫，这表明T细胞在对该寄生虫的获得性免疫中发挥作用。使用尼龙毛柱从免疫小鼠的脾脏中制备富集的T细胞和B细胞群体，并将其过继转移到同基因未照射的小鼠或接受600或800拉德照射的小鼠体内。通常，一些免疫力可以通过免疫T细胞、B细胞和经玻璃棉（g.w.）过滤的脾细胞群体进行转移。在接受大量照射的小鼠中，经g.w.过滤的免疫脾细胞提供了最佳保护，而免疫T细胞提供的保护最少。在照射小鼠中显示免疫T细胞和B细胞之间协同活性的初步尝试未成功。
