年龄对纤维蛋白溶解酶系统的影响。
The effect of age on the fibrinolytic enzyme system.
作者信息
Hamilton P J, Dawson A A, Ogston D, Douglas A S
出版信息
J Clin Pathol. 1974 Apr;27(4):326-9. doi: 10.1136/jcp.27.4.326.
Abstract
Components of the fibrinolytic enzyme system, FR-antigen and fibrinogen, were measured in 20 healthy volunteers aged 20-40 years and in 61 elderly subjects aged 66-96 years. Plasminogen activator levels did not significantly differ between the 20-40 and 66-75 age groups, but were higher in those over 75. Plasminogen showed no change with age except for a fall in those over 75. Fibrinogen, FR-antigen, alpha(1)-antitrypsin, and alpha(2)-macroglobulin all rose with age, but the mean fibrinogen concentration fell in the very elderly.
摘要
在20名年龄在20至40岁的健康志愿者以及61名年龄在66至96岁的老年人中，对纤维蛋白溶解酶系统的组成成分、纤维蛋白溶解酶原激活剂抗原（FR抗原）和纤维蛋白原进行了测量。20至40岁年龄组与66至75岁年龄组之间的纤溶酶原激活剂水平无显著差异，但75岁以上人群的该水平更高。除75岁以上人群有所下降外，纤溶酶原水平未随年龄变化。纤维蛋白原、FR抗原、α1抗胰蛋白酶和α2巨球蛋白均随年龄增长而升高，但极高龄老年人的纤维蛋白原平均浓度下降。
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