HUME R
J Clin Pathol. 1961 Mar;14(2):167-71. doi: 10.1136/jcp.14.2.167.
Three ;normal' groups of people-young, middle-aged, and old-have been investigated with regard to the fibrin content and fibrinolytic activity of the blood. The fourth group consisted of middle-aged people who had previously sustained a cerebral vascular accident matched statistically for age with the middle-aged normals. It was concluded that fibrin increases with age but there is an interaction between age and sex, the female having a higher level in the young group and the male a higher level in the middle-aged group. There was no sex difference in the levels of fibrin in the old age group. Fibrinolytic activity increases with age and there is a positive correlation between fibrin and fibrinolytic activity but no age-sex interaction. Those with cerebral vascular accidents tended to have higher fibrin levels and lower fibrinolytic activity but the differences were not statistically significant. There did, however, appear to be an increase in antifibrinolytic activity in the cerebral vascular group.
对三组“正常”人群——年轻人、中年人和老年人——的血液纤维蛋白含量和纤维蛋白溶解活性进行了研究。第四组由曾发生过脑血管意外的中年人组成，在年龄上与中年正常人群进行了统计学匹配。研究得出结论，纤维蛋白含量随年龄增长而增加，但年龄与性别之间存在相互作用，在年轻组中女性的纤维蛋白水平较高，而在中年组中男性的纤维蛋白水平较高。老年组中纤维蛋白水平不存在性别差异。纤维蛋白溶解活性随年龄增长而增加，并且纤维蛋白与纤维蛋白溶解活性之间存在正相关，但不存在年龄-性别相互作用。发生过脑血管意外的人群往往纤维蛋白水平较高且纤维蛋白溶解活性较低，但差异无统计学意义。然而，脑血管意外组的抗纤维蛋白溶解活性似乎有所增加。
