Turusov V S, Linnik A B, Morozova O V, Parfenov Iu D
Eksp Onkol. 1984;6(2):20-3.
The results of combined treatment of CBA female mice with 1,2-dimethylhydrazine (DMH) and estradiol dipropionate (EP) are discussed in terms of a two-stage carcinogenesis hypothesis. 20% of mice treated with DMH alone developed uterine sarcomas. EP given after the cessation of DMH-treatment increased sarcoma incidence as high as 60.6% (5 micrograms EP) or 66.7% (10 micrograms EP) and significantly decreased the time of the first tumour appearance. From the standpoint of the two-stage carcinogenesis it is considered possible for EP to influence the tumour-initiating stage.
根据两阶段致癌假说，讨论了用1,2 - 二甲基肼（DMH）和二丙酸雌二醇（EP）联合治疗CBA雌性小鼠的结果。单独用DMH治疗的小鼠中有20%发生了子宫肉瘤。在DMH治疗停止后给予EP，肉瘤发生率高达60.6%（5微克EP）或66.7%（10微克EP），并显著缩短了首次出现肿瘤的时间。从两阶段致癌的角度来看，EP有可能影响肿瘤起始阶段。
