Turusov V S, Linnik A B, Morozova O V
Biull Eksp Biol Med. 1980 Nov;90(11):599-600.
CBA female mice received weekly subcutaneous injections of 1,2-dimethylhydrazine (1,2-DMH) in a dose of 8 mg/kg for 10 weeks (group 1). In groups 2,3 and 4 1,2-DMH plus estradiol dipropionate were administered for 10, 20 or 25 weeks, respectively. The incidence of uterine sarcoma in groups 1, 2, 3 and 4 was 3.3, 2.5, 65.4 and 73%, respectively. The mice given estradiol dipropionate alone developed no uterine sarcomas. Possible mechanisms of the uterine sarcomogenesis stimulation by estrogen are discussed.
CBA 雌性小鼠每周皮下注射剂量为 8 毫克/千克的 1,2 - 二甲基肼（1,2 - DMH），持续 10 周（第 1 组）。在第 2、3 和 4 组中，分别给予 1,2 - DMH 加二丙酸雌二醇，持续 10、20 或 25 周。第 1、2、3 和 4 组子宫肉瘤的发生率分别为 3.3%、2.5%、65.4%和 73%。单独给予二丙酸雌二醇的小鼠未发生子宫肉瘤。文中讨论了雌激素刺激子宫肉瘤发生的可能机制。
