针对猿类和人类疟原虫子孢子的抗体反应：其阶段和物种特异性以及菌株交叉反应性。
The antibody response to sporozoites of simian and human malaria parasites: its stage and species specificity and strain cross-reactivity.
作者信息
Nussenzweig R S, Chen D
出版信息
Bull World Health Organ. 1974;50(3-4):293-7.
Abstract
Attempts to vaccinate against malaria are currently being pursued in both simian hosts and human volunteers, using X-irradiated sporozoites as antigen. The present experiments provide information on the developmental stage during which simian malaria sporozoites acquire certain antigen(s) and become infective, and on the antigenic similarities between sporozoites of different strains and species of simian and human malaria parasites. Such knowledge should prove of value in the choice of sporozoite preparations for future attempts at vaccination.
摘要
目前正在使用经X射线照射的子孢子作为抗原，在猿类宿主和人类志愿者身上开展抗疟疾疫苗接种的尝试。本实验提供了关于猿类疟原虫子孢子获得某些抗原并具有感染性的发育阶段的信息，以及不同菌株和种类的猿类及人类疟原虫子孢子之间的抗原相似性的信息。这些知识在为未来的疫苗接种尝试选择子孢子制剂方面应具有价值。
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本文引用的文献
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