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1
The antibody response to sporozoites of simian and human malaria parasites: its stage and species specificity and strain cross-reactivity.针对猿类和人类疟原虫子孢子的抗体反应：其阶段和物种特异性以及菌株交叉反应性。
Bull World Health Organ. 1974;50(3-4):293-7.
2
Some characteristics of the immune response to sporozoites of simian and human malaria.对猿类和人类疟原虫子孢子免疫反应的一些特征。
Bull Pan Am Health Organ. 1974;8(3):198-204.
3
Specificity of the circum-sporozoite precipitation antigen(s) of human and simian malarias.人和猿类疟疾环子孢子沉淀抗原的特异性
J Parasitol. 1976 Aug;62(4):636-7.
4
Antibodies against sporozoites of human and simian malaria produced in rats.在大鼠体内产生的针对人类和猿类疟疾子孢子的抗体。
J Immunol. 1973 Feb;110(2):600-1.
5
Characterization of sporozoite surface antigens by indirect immunofluorescence: detection of stage- and species-specific antimalarial antibodies.通过间接免疫荧光法对疟原虫表面抗原进行表征：检测阶段特异性和种特异性抗疟抗体。
Bull World Health Organ. 1979;57 Suppl 1(Suppl):211-7.
6
Preliminary studies on vaccination of rhesus monkeys with irradiated sporozoites of Plasmodium knowlesi and characterization of surface antigens of these parasites.用诺氏疟原虫辐照子孢子对恒河猴进行疫苗接种及这些寄生虫表面抗原特性的初步研究。
Bull World Health Organ. 1979;57 Suppl 1(Suppl):165-73.
7
Malaria vaccination with irradiated sporozoites: serological evaluation of the antigen and antibody responses.用辐照子孢子进行疟疾疫苗接种：抗原和抗体反应的血清学评估。
Bull World Health Organ. 1979;57 Suppl 1(Suppl):205-9.
8
Crossreactivity with sporozoites, exoerythrocytic forms and blood schizonts of Plasmodium berghei in indirect fluorescent antibody tests with sera of rats immunized with sporozoites or infected blood.在用子孢子或感染血液免疫的大鼠血清进行的间接荧光抗体试验中，与伯氏疟原虫的子孢子、红细胞外期形态和血内裂殖体存在交叉反应。
Clin Exp Immunol. 1977 Jul;29(1):43-51.
9
Rodent malaria in the natural host--irradiated sporozoites of Plasmodium berghei induce liver-stage specific immune responses in the natural host Grammomys surdaster and protect immunized Grammomys against P. berghei sporozoite challenge.自然宿主中的啮齿类疟疾——伯氏疟原虫的辐照子孢子在自然宿主粗硬非洲巨鼠中诱导肝期特异性免疫反应，并保护免疫后的粗硬非洲巨鼠免受伯氏疟原虫子孢子攻击。
Afr J Med Med Sci. 2001;30 Suppl:25-33.
10
Antibody responses of patients with natural malaria to human and simian plasmodium antigens measured by the fluorescent antibody test.通过荧光抗体试验测定的自然感染疟疾患者对人和猿疟原虫抗原的抗体反应。
Trop Geogr Med. 1968 Jun;20(2):137-40.

引用本文的文献

1
Sporozoite immunization: innovative translational science to support the fight against malaria.子孢子免疫接种：支持抗击疟疾的创新转化科学。
Expert Rev Vaccines. 2023 Jan-Dec;22(1):964-1007. doi: 10.1080/14760584.2023.2245890. Epub 2023 Aug 11.
2
Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens.蚊叮诱导的间日疟原虫或恶性疟原虫人工感染可引起针对同源和异源红细胞前期和红细胞期抗原的免疫应答。
Infect Immun. 2019 Feb 21;87(3). doi: 10.1128/IAI.00541-18. Print 2019 Mar.
3
Antibodies elicited during natural infection in a predominantly Plasmodium falciparum transmission area cross-react with sexual stage-specific antigen in P. vivax.在以恶性疟原虫传播为主的地区自然感染期间产生的抗体与间日疟原虫的性阶段特异性抗原有交叉反应。
Acta Trop. 2017 Jun;170:105-111. doi: 10.1016/j.actatropica.2017.02.032. Epub 2017 Feb 28.
4
The biology of Plasmodium in the mosquito.
Experientia. 1984 Dec 15;40(12):1330-43. doi: 10.1007/BF01951886.
5
Immunology of malaria.疟疾免疫学
Indian J Pediatr. 1985 May-Jun;52(416):269-73. doi: 10.1007/BF02754856.
6
Developmentally regulated infectivity of malaria sporozoites for mosquito salivary glands and the vertebrate host.疟原虫子孢子对蚊唾液腺和脊椎动物宿主的发育调控感染性。
J Exp Med. 1992 Jun 1;175(6):1607-12. doi: 10.1084/jem.175.6.1607.
7
Immunobiology of malaria.疟疾的免疫生物学
J Natl Med Assoc. 1979 Apr;71(4):349-51.
8
Characterization of sporozoite surface antigens by indirect immunofluorescence: detection of stage- and species-specific antimalarial antibodies.通过间接免疫荧光法对疟原虫表面抗原进行表征：检测阶段特异性和种特异性抗疟抗体。
Bull World Health Organ. 1979;57 Suppl 1(Suppl):211-7.
9
Recent advances in applied malaria immunology.应用疟疾免疫学的最新进展
Z Parasitenkd. 1979 Nov;60(1):3-17. doi: 10.1007/BF00928967.
10
In vitro cultivation of the sporogonic stages of Plasmodium: a review.疟原虫孢子生殖阶段的体外培养：综述
Bull World Health Organ. 1977;55(2-3):377-92.

本文引用的文献

1
Specificity of protective immunity produced by x-irradiated Plasmodium berghei sporozoites.
Nature. 1969 May 3;222(5192):488-9. doi: 10.1038/222488a0.
2
Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. V. In vitro effects of immune serum on sporozoites.注射经X射线照射的伯氏疟原虫子孢子产生的保护性免疫。V. 免疫血清对子孢子的体外作用。
Mil Med. 1969 Sep;134(10):1183-90.
3
Immunization of monkeys against Plasmodium cynomolgi by X-irradiated sporozoites.用X射线照射的子孢子对猕猴进行食蟹猴疟原虫免疫接种。
Nat New Biol. 1972 Apr 12;236(67):176-7. doi: 10.1038/newbio236176a0.

针对猿类和人类疟原虫子孢子的抗体反应：其阶段和物种特异性以及菌株交叉反应性。

The antibody response to sporozoites of simian and human malaria parasites: its stage and species specificity and strain cross-reactivity.

作者信息

Nussenzweig R S, Chen D

出版信息

Bull World Health Organ. 1974;50(3-4):293-7.

PMID:4548393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2481184/
Abstract

Attempts to vaccinate against malaria are currently being pursued in both simian hosts and human volunteers, using X-irradiated sporozoites as antigen. The present experiments provide information on the developmental stage during which simian malaria sporozoites acquire certain antigen(s) and become infective, and on the antigenic similarities between sporozoites of different strains and species of simian and human malaria parasites. Such knowledge should prove of value in the choice of sporozoite preparations for future attempts at vaccination.

摘要

目前正在使用经X射线照射的子孢子作为抗原，在猿类宿主和人类志愿者身上开展抗疟疾疫苗接种的尝试。本实验提供了关于猿类疟原虫子孢子获得某些抗原并具有感染性的发育阶段的信息，以及不同菌株和种类的猿类及人类疟原虫子孢子之间的抗原相似性的信息。这些知识在为未来的疫苗接种尝试选择子孢子制剂方面应具有价值。