Rennison B D
J Hyg (Lond). 1974 Dec;73(3):361-7. doi: 10.1017/s0022172400042704.
The effectiveness of calciferol (vitamin D(2)) against Rattus norvegicus was investigated in field trials on twenty-three farms with rat infestations partly resistant to warfarin. At 0.01% combined with warfarin at 0.025% no rodenticidal effect of the calciferol was discernible. At 0.025% with warfarin at the same concentration, results were better, but not appreciably better than is often obtained with warfarin alone against resistant rat populations. When the concentration of calciferol was stepped up to 0.1%, four out of five treatments in which the poison was applied directly gave complete control. The fifth may have partly failed because of poison shyness caused by under-baiting. Five out of six more treatments done after ;pre-baiting' were also successful. The sixth failed for reasons unconnected with the choice of poison.Six further infestations that were not responding adequately to warfarin treatments were quickly controlled when, in three instances, calciferol at 0.1% was used instead and, in three more, it was used together with warfarin. It is concluded that calciferol at 0.1% is an effective poison against R. norvegicus either combined with warfarin or not, but that because at 0.1% its effect is subacute rather than chronic, there may be a case in some environments for using it only after pre-baiting.
在23个有对杀鼠灵产生部分抗性的鼠害的农场进行了田间试验，以研究骨化醇（维生素D₂）对褐家鼠的有效性。当骨化醇与0.025%的杀鼠灵混合使用时，浓度为0.01%，未发现骨化醇有杀鼠效果。当骨化醇与相同浓度（0.025%）的杀鼠灵混合使用时，效果较好，但并不比单独使用杀鼠灵对付抗性鼠群时通常获得的效果明显更好。当骨化醇的浓度提高到0.1%时，在直接投放毒饵的五次处理中，有四次实现了完全控制。第五次处理可能部分失败是因为投饵不足导致了鼠类对毒饵的回避。在“预投饵”后进行的另外六次处理中，有五次也取得了成功。第六次处理失败与毒饵的选择无关。另外六处对杀鼠灵处理反应不佳的鼠害，在三种情况下改用0.1%的骨化醇，在另外三种情况下将其与杀鼠灵一起使用后，很快得到了控制。得出的结论是，0.1%的骨化醇无论是与杀鼠灵混合使用还是单独使用，都是对付褐家鼠的有效毒药，但由于其在0.1%浓度时的作用是亚急性而非慢性的，在某些环境下可能只有在预投饵后才使用它。
