啮齿动物对抗凝血剂耐药性的检测。
The detection of rodent resistance to anticoagulants.
作者信息
Drummond D C, Rennison B D
出版信息
Bull World Health Organ. 1973;48(2):239-42.
The procedures used in the United Kingdom to detect anticoagulant resistance in the Norway rat are described. Preliminary inspections are made of the suspect rat populations to exclude other possible causes of control failure. The inspections are followed by carefully supervised warfarin treatments in which the feeding pattern over 2-3 weeks is compared with that of normal rats. If rats continue to take the bait longer than is usual, laboratory tests are undertaken on trapped animals. It is believed that the methods will be found to be generally applicable to the investigation of anticoagulant resistance in other rodents in many parts of the world.
本文描述了英国用于检测挪威大鼠对抗凝剂耐药性的程序。首先对可疑大鼠群体进行初步检查，以排除其他可能导致灭鼠失败的原因。随后进行严格监督下的华法林治疗，将2至3周内的投饵模式与正常大鼠进行比较。如果大鼠食用诱饵的时间比正常情况长，则对捕获的动物进行实验室检测。据信，这些方法将普遍适用于世界许多地区其他啮齿动物对抗凝剂耐药性的调查。
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