• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

麻风病的组织学分类与免疫谱

Histological classification and the immunological spectrum of leprosy.

作者信息

Ridley D S

出版信息

Bull World Health Organ. 1974;51(5):451-65.

PMID:4549496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2366326/
Abstract

The clinical and histological manifestations of leprosy are known to be closely correlated with the immunological state of the patient, which determines prognosis and constitutes the natural basis for the classification of this disease. A classification based on this correlation has come to be widely used but needs to be brought up to date and expanded in the light of more recent experience. The author of the present paper presents a much fuller account of the histological side of the classification, taking into account the results of recent experience. This histological classification has been found to provide a workable and widely applicable system, different histologists achieving remarkably good agreement with one another.

摘要

已知麻风病的临床和组织学表现与患者的免疫状态密切相关，免疫状态决定预后，并构成该疾病分类的自然基础。基于这种相关性的分类已被广泛使用，但需要根据最新经验进行更新和扩展。本文作者根据最近的经验，对分类的组织学方面进行了更更更全面的阐述。已发现这种组织学分类提供了一个可行且广泛适用的系统，不同的组织学家之间达成了非常好的共识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/333a613fa280/bullwho00471-0024-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/abe90f6dc1f7/bullwho00471-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/ce618e892ff5/bullwho00471-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/b9ee75521db6/bullwho00471-0021-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/77ff2933010b/bullwho00471-0021-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/c88b8eb9bebf/bullwho00471-0021-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/cc16b56bcf89/bullwho00471-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/c22cb29e0878/bullwho00471-0022-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/4073d8a78682/bullwho00471-0022-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/89f688ff8e5d/bullwho00471-0022-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/0198ba76e7fe/bullwho00471-0022-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/b5dcd4ca3a8d/bullwho00471-0022-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/f4bf72e025a0/bullwho00471-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/76232c1da02d/bullwho00471-0023-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/99425db3b198/bullwho00471-0023-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/2a5de7ab6c3c/bullwho00471-0023-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/e4fb7b90cc7b/bullwho00471-0023-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/672c965be417/bullwho00471-0023-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/1111c368e3b9/bullwho00471-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/c257b85e69e1/bullwho00471-0024-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/9d375584c5d2/bullwho00471-0024-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/333a613fa280/bullwho00471-0024-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/abe90f6dc1f7/bullwho00471-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/ce618e892ff5/bullwho00471-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/b9ee75521db6/bullwho00471-0021-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/77ff2933010b/bullwho00471-0021-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/c88b8eb9bebf/bullwho00471-0021-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/cc16b56bcf89/bullwho00471-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/c22cb29e0878/bullwho00471-0022-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/4073d8a78682/bullwho00471-0022-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/89f688ff8e5d/bullwho00471-0022-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/0198ba76e7fe/bullwho00471-0022-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/b5dcd4ca3a8d/bullwho00471-0022-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/f4bf72e025a0/bullwho00471-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/76232c1da02d/bullwho00471-0023-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/99425db3b198/bullwho00471-0023-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/2a5de7ab6c3c/bullwho00471-0023-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/e4fb7b90cc7b/bullwho00471-0023-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/672c965be417/bullwho00471-0023-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/1111c368e3b9/bullwho00471-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/c257b85e69e1/bullwho00471-0024-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/9d375584c5d2/bullwho00471-0024-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83c8/2366326/333a613fa280/bullwho00471-0024-d.jpg

相似文献

1
Histological classification and the immunological spectrum of leprosy.麻风病的组织学分类与免疫谱
Bull World Health Organ. 1974;51(5):451-65.
2
Correlation of clinical, histological and immunological features across the leprosy spectrum.
Indian J Lepr. 2001 Oct-Dec;73(4):329-42.
3
Correlation of clinical and histopathological studies in classification of leprosy.麻风病分类中临床与组织病理学研究的相关性
Lepr India. 1981 Oct;53(4):562-5.
4
Positioning of borderline and indetermined groups in the hanseniasis classification.
Hansenol Int. 1981 Jun;6(1):63-70.
5
Leprosy classification for use in control programs.
Hansenol Int. 1981 Dec;6(2):130-5.
6
Some aspects of tuberculoid leprosy and chemotherapeutic trials.结核样型麻风及化疗试验的某些方面
Acta Leprol. 1979 Jan-Mar(74):II-IV,1-32.
7
Allocation of patients to paucibacillary or multibacillary drug regimens for the treatment of leprosy--a comparison of methods based mainly on skin smears as opposed to clinical methods--alternative clinical methods for classification of patients.将患者分配至多菌型或少菌型药物治疗方案以治疗麻风病——主要基于皮肤涂片的方法与临床方法的比较——患者分类的替代临床方法
Int J Lepr Other Mycobact Dis. 1991 Jun;59(2):292-303.
8
Variations in clinical and histopathological classification of leprosy--a report and a plausible explanation.麻风病临床和组织病理学分类的差异——一份报告及一种合理的解释
Lepr India. 1983 Jul;55(3):472-9.
9
Significance of histopathological classification in leprosy.麻风病组织病理学分类的意义。
Indian J Lepr. 1999 Jul-Sep;71(3):325-32.
10
Clinical and histopathological correlation in the classification of leprosy.麻风病分类中的临床与组织病理学相关性
Int J Lepr Other Mycobact Dis. 1993 Sep;61(3):433-8.

引用本文的文献

1
B-cell subsets in leprosy lesions: unraveling the complex interplay.麻风病损中的B细胞亚群：揭示复杂的相互作用
An Bras Dermatol. 2025 Aug 9;100(5):501184. doi: 10.1016/j.abd.2025.501184.
2
Decoding leprosy: immune response, clinical manifestations and emerging diagnostic approaches.麻风病解码：免疫反应、临床表现及新兴诊断方法
Trans R Soc Trop Med Hyg. 2025 Sep 2;119(9):988-998. doi: 10.1093/trstmh/traf058.
3
Case Report: Nonalcoholic Hepatic Steatosis Associated with Type-2 Leprosy Reaction.病例报告：与 2 型麻风反应相关的非酒精性脂肪性肝病。

本文引用的文献

1
A classification of leprosy for research purposes.用于研究目的的麻风病分类。
Lepr Rev. 1962 Apr;33:119-28. doi: 10.5935/0305-7518.19620014.
2
REACTION OF THE DERMIS IN LEPROSY.麻风病中真皮的反应
Int J Lepr. 1964 Jan-Mar;32:24-36.
3
Therapeutic trials in leprosy using serial biopsies.采用连续活检进行的麻风病治疗试验。
Am J Trop Med Hyg. 2024 Jul 2;111(3):560-564. doi: 10.4269/ajtmh.23-0874. Print 2024 Sep 4.
4
A half-century of research on tuberculosis: Successes and challenges.半个世纪的结核病研究：成就与挑战。
J Exp Med. 2023 Sep 4;220(9). doi: 10.1084/jem.20230859. Epub 2023 Aug 8.
5
Dendritic Cell Activation in Leprosy Using CD1a and Factor XIIIa Markers.利用CD1a和凝血因子XIIIa标记物研究麻风病中树突状细胞的激活情况。
Cureus. 2023 Apr 22;15(4):e37968. doi: 10.7759/cureus.37968. eCollection 2023 Apr.
6
Activated TLR2/4-positive T cells boost cell exhaustion during lepromatous leprosy infection via PD-1 upregulation.活化的TLR2/4阳性T细胞通过上调PD-1在瘤型麻风感染期间促进细胞耗竭。
Heliyon. 2022 Nov 15;8(11):e11633. doi: 10.1016/j.heliyon.2022.e11633. eCollection 2022 Nov.
7
Pathogenicity and virulence of . 的致病性和毒力。
Virulence. 2022 Dec;13(1):1985-2011. doi: 10.1080/21505594.2022.2141987.
8
Gene expression patterns associated with multidrug therapy in multibacillary leprosy.与多药治疗多菌型麻风相关的基因表达模式。
Front Cell Infect Microbiol. 2022 Jul 22;12:917282. doi: 10.3389/fcimb.2022.917282. eCollection 2022.
9
Correlation of Histomorphological Findings with Bacteriological Index in Leprosy Patients.麻风病患者组织形态学结果与细菌学指标的相关性
Iran J Pathol. 2022 Winter;17(1):48-55. doi: 10.30699/IJP.2021.534122.2682. Epub 2021 Dec 15.
10
Treatment and Evaluation Advances in Leprosy Neuropathy.麻风神经病变的治疗和评估进展。
Neurotherapeutics. 2021 Oct;18(4):2337-2350. doi: 10.1007/s13311-021-01153-z. Epub 2021 Nov 19.
Lepr Rev. 1958 Jan;29(1):45-52. doi: 10.5935/0305-7518.19580004.
4
Reactions in leprosy.麻风病中的反应
Lepr Rev. 1969 Apr;40(2):77-81. doi: 10.5935/0305-7518.19690016.
5
Significance of variations within the lepromatous group.瘤型组内变异的意义。
Lepr Rev. 1969 Jul;40(3):143-52. doi: 10.5935/0305-7518.19690026.
6
A logarithmic index of bacilli in biopsies. 2. Evaluation.
Int J Lepr Other Mycobact Dis. 1967 Apr-Jun;35(2):187-93.
7
The impact of experimental human leprosy in the mouse on leprosy research.
Int J Lepr Other Mycobact Dis. 1971 Apr-Jun;39(2):201-15.
8
Immunological significance of changes in lymph nodes across the leprosy spectrum.麻风病谱中淋巴结变化的免疫学意义。
Clin Exp Immunol. 1971 Mar;8(3):363-76.
9
Mechanism of "reactions" in borderline tuberculoid (BT) leprosy. A preliminary report.界线类偏结核样型（BT）麻风“反应”的机制。初步报告。
Acta Pathol Microbiol Scand Suppl. 1973;236(0):45-53.
10
Macrophage accumulation, division, maturation, and digestive and microbicidal capacities in tuberculous lesions. IV. Macrophage turnover, lysosomal enzymes, and division in healing lesions.结核病变中巨噬细胞的聚集、分裂、成熟以及消化和杀菌能力。IV. 愈合病变中的巨噬细胞更新、溶酶体酶及分裂
Lab Invest. 1972 Nov;27(5):466-72.