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病例报告:与 2 型麻风反应相关的非酒精性脂肪性肝病。

Case Report: Nonalcoholic Hepatic Steatosis Associated with Type-2 Leprosy Reaction.

机构信息

Servicio de Infectología, IMAT ONCOMEDICA Auna, Montería, Columbia.

Servicio de Medicina General, IMAT ONCOMEDICA Auna, Montería, Colombia.

出版信息

Am J Trop Med Hyg. 2024 Jul 2;111(3):560-564. doi: 10.4269/ajtmh.23-0874. Print 2024 Sep 4.

DOI:10.4269/ajtmh.23-0874
PMID:38955201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11376155/
Abstract

Leprosy reactions are complex immune events, generating disabling consequences and threatening the lives of those who experience them. This case report addresses the episode of a 28-year-old female patient who suffered a severe type-2 leprosy reaction, characterized by significant hepatic involvement, specifically, nonalcoholic hepatic steatosis. This case report underscores the importance of maintaining a high level of clinical suspicion, early recognition, accurate diagnosis, and immediate addressing of these types of reactions that may arise in the context of leprosy.

摘要

麻风反应是复杂的免疫事件,会产生致残后果,威胁到经历这些反应的人的生命。本病例报告介绍了一位 28 岁女性患者的发病经过,她患有严重的 2 型麻风反应,其特征是肝明显受累,具体表现为非酒精性肝脂肪变性。本病例报告强调了在麻风病背景下可能出现的这些类型反应,要保持高度的临床警惕、早期识别、准确诊断和及时处理的重要性。

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本文引用的文献

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Case Report: Necrotizing Erythema Nodosum as a Manifestation of Lepromatous Leprosy Relapse 50 Years after the Initial Infection.病例报告:初染后 50 年,坏死性结节红斑作为麻风复发的表现。
Am J Trop Med Hyg. 2023 May 30;109(1):53-56. doi: 10.4269/ajtmh.22-0701. Print 2023 Jul 5.
2
Leprosy: A Review of Epidemiology, Clinical Diagnosis, and Management.麻风病:流行病学、临床诊断与管理综述
J Trop Med. 2022 Jul 4;2022:8652062. doi: 10.1155/2022/8652062. eCollection 2022.
3
Mycobacterium lepromatosis as Cause of Leprosy, Colombia.麻风分枝杆菌致麻风,哥伦比亚。
Emerg Infect Dis. 2022 May;28(5):1067-1068. doi: 10.3201/eid2805.212015.
4
Leprosy Reactions and Neuropathic Pain in Pure Neural Leprosy in a Reference Center in Rio de Janeiro - Brazil.巴西里约热内卢一个参考中心的纯神经型麻风病中的麻风反应和神经性疼痛
Front Med (Lausanne). 2022 Mar 25;9:865485. doi: 10.3389/fmed.2022.865485. eCollection 2022.
5
Lucio's phenomenon: A systematic literature review of definition, clinical features, histopathogenesis and management.卢西奥现象:定义、临床特征、组织病理学发病机制和治疗的系统文献综述。
Indian J Dermatol Venereol Leprol. 2022 May-Jun;88(4):464-477. doi: 10.25259/IJDVL_909_19.
6
What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum.麻风结节性红斑的发病机制与治疗有哪些新进展。
Indian Dermatol Online J. 2020 Jul 13;11(4):482-492. doi: 10.4103/idoj.IDOJ_561_19. eCollection 2020 Jul-Aug.
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J Am Acad Dermatol. 2020 Jul;83(1):17-30. doi: 10.1016/j.jaad.2019.10.138. Epub 2020 Mar 31.
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Trans R Soc Trop Med Hyg. 2017 Mar 1;111(3):125-131. doi: 10.1093/trstmh/trx026.
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