免疫抑制小鼠细胞的体外脾白细胞迁移及植物血凝素刺激的淋巴细胞转化。II. 经硫唑嘌呤和/或免疫刺激或胸腺切除处理的小鼠细胞。
In vitro spleen leucocyte migration and phytohaemagglutinin-stimulated lymphocyte transformation of immunosuppressed mice cells. II. Cells from mice treated by azathioprine and/or immune stimulation or thymectomy.
作者信息
House A K, Boak J L, Draper V
出版信息
Clin Exp Immunol. 1974 May;17(1):189-98.
An study of the spleen leucocyte migration ability and the phytohaemag-glutinin (PHA) stimulated peripheral lymphocyte response was made on cells derived from mice treated by azathioprine, immune stimulation, or thymectomy and azathioprine. These responses were compared with those shown by normal mice and found to be considerably depressed. Thymectomy combined with azathioprine produced the greatest change which persisted at 40 days. These changes suggested that azathioprine in common with thymectomy, antilymphocyte globulin and radiotherapy produced some of its immunosuppression by depressing T-cell function.
对用硫唑嘌呤、免疫刺激或胸腺切除加硫唑嘌呤处理的小鼠来源的细胞进行了脾脏白细胞迁移能力和植物血凝素（PHA）刺激的外周淋巴细胞反应的研究。将这些反应与正常小鼠的反应进行比较，发现其明显受到抑制。胸腺切除联合硫唑嘌呤产生的变化最大，且在40天时仍持续存在。这些变化表明，硫唑嘌呤与胸腺切除、抗淋巴细胞球蛋白和放射疗法一样，通过抑制T细胞功能产生了一些免疫抑制作用。
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