小鼠在自然感染中对鼠白血病病毒的抗体反应：缺乏经典免疫耐受性（AKR小鼠-补体结合抗体-淋巴细胞性脉络丛脑膜炎病毒-免疫荧光-抗原抗体复合物的肾小球沉积物）
The antibody response of mice to murine leukemia virus in spontaneous infection: absence of classical immunologic tolerance (AKR mice-complement-fixing antibodies-lymphocytic choriomeningitis virus-immunofluorescence-glomerular deposits of antigen-antibody complexes).
作者信息
Oldstone M B, Aoki T, Dixon F J
出版信息
Proc Natl Acad Sci U S A. 1972 Jan;69(1):134-8. doi: 10.1073/pnas.69.1.134.
Abstract
Gross murine leukemia virus is the etiologic agent of spontaneous leukemias of AKR mice. Despite the persistence of the Gross virus throughout their life, these mice are not immunologically tolerant to the virus. Specific antibodies to Gross antigens can be detected in the kidney where they have been deposited in the glomeruli, apparently in the form of Gross antigen-antibody complexes.
摘要
莫氏鼠白血病病毒是AKR小鼠自发性白血病的病原体。尽管莫氏病毒在这些小鼠一生中持续存在，但它们对该病毒并不产生免疫耐受。在肾脏中可检测到针对莫氏抗原的特异性抗体，这些抗体显然以莫氏抗原-抗体复合物的形式沉积在肾小球中。
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