Wirman J A, Crissman J D, Aron B F
Cancer. 1979 Jul;44(1):87-93. doi: 10.1002/1097-0142(197907)44:1<87::aid-cncr2820440116>3.0.co;2-j.
Although most chondroblastomas are cured by limited surgical procedures, occasional lesions behave more aggressively and may even metastasize. We report here an unusual case of chondroblastoma, characterized by slow growth, two clinical recurrences following attempts at excision, and pulmonary metastases after a total course of 34 years. This tumor was moderately radiosensitive, as it decreased 50% in size 6 months after a dose of 4000 rads in 4 weeks. Review of the literature suggests that aggressive chondroblastomas may show several types of behavior. Most lesions are unusually aggressive from their inception, displaying local invasion and early recurrence. Other lesions, such as the present case, continue to grow slowly and may eventually metastasize if inadequately resected. This latter type of behavior may exemplify the natural history of untreated chondroblastoma.
尽管大多数软骨母细胞瘤可通过有限的手术程序治愈，但偶尔会有一些病变表现得更为侵袭性，甚至可能发生转移。我们在此报告一例不寻常的软骨母细胞瘤病例，其特点是生长缓慢，在尝试切除后临床复发两次，并在病程长达34年后出现肺转移。该肿瘤对放射治疗有中度敏感性，在4周内给予4000拉德剂量后6个月，其大小缩小了50%。文献回顾表明，侵袭性软骨母细胞瘤可能表现出几种不同的行为类型。大多数病变从一开始就具有异常的侵袭性，表现为局部侵犯和早期复发。其他病变，如本病例，继续缓慢生长，如果切除不充分，最终可能发生转移。后一种行为类型可能例证了未经治疗的软骨母细胞瘤的自然病程。
