• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate.

作者信息

Moyer J D, Handschumacher R E

出版信息

Cancer Res. 1979 Aug;39(8):3089-94.

PMID:455293
Abstract
摘要

相似文献

1
Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate.N-（膦酰乙酰基）-L-天冬氨酸对嘧啶合成的选择性抑制及核苷酸库的耗竭
Cancer Res. 1979 Aug;39(8):3089-94.
2
Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells.N-（膦酰乙酰基）-L-天冬氨酸和吡唑呋林对完整细胞和通透细胞中嘧啶核糖核苷酸池和脱氧核糖核苷酸池的消耗动力学及其与核酸合成的关系。
Cancer Res. 1982 Nov;42(11):4525-31.
3
Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid.与从头嘧啶合成抑制剂、阿西维辛和N-（膦酰乙酰基）-L-天冬氨酸的协同作用。
Cancer Res. 1981 Sep;41(9 Pt 1):3419-23.
4
Flux through the de novo pyrimidine pathway in vivo. Effect of N-phosphonacetyl-L-aspartate, a potent inhibitor of aspartate transcarbamylase.体内从头嘧啶途径的通量。天冬氨酸转氨甲酰酶的强效抑制剂N-膦酰乙酰-L-天冬氨酸的作用。
J Biol Chem. 1983 Nov 25;258(22):13564-9.
5
Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.Lewis肺癌变体对N-（膦酰乙酰基）-L-天冬氨酸的耐药机制
Cancer Res. 1981 Mar;41(3):894-904.
6
Effect of inhibitors of the de novo pyrimidine biosynthetic pathway on serum uridine levels in mice.从头嘧啶生物合成途径抑制剂对小鼠血清尿苷水平的影响。
Cancer Res. 1981 Dec;41(12 Pt 1):4952-5.
7
Effects of acivicin and PALA, singly and in combination, on de novo pyrimidine biosynthesis.阿西维辛和N-(膦酰乙酰)-L-天冬氨酸单独及联合使用对嘧啶从头生物合成的影响。
Adv Enzyme Regul. 1982;20:57-73. doi: 10.1016/0065-2571(82)90008-5.
8
Selective inhibition of pyrimidine biosynthesis and effect on proliferative growth of colonic cancer cells.嘧啶生物合成的选择性抑制及其对结肠癌细胞增殖生长的影响。
Cancer Res. 1977 Sep;37(9):3080-7.
9
Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase.N-（膦酰基乙酰基）-L-天冬氨酸对小鼠肿瘤及正常组织的体内外作用以及敏感性与增殖速率和天冬氨酸转氨甲酰酶水平的关系
Cancer Res. 1978 Feb;38(2):371-8.
10
Salvage of circulating pyrimidine nucleosides in the rat.大鼠体内循环嘧啶核苷的挽救作用。
Cancer Res. 1981 Aug;41(8):3010-7.

引用本文的文献

1
Effect of Uridine on the Metabolism of 5-Fluorouracil in the CD8F 1 Murine Mammary Carcinoma System.尿苷对 CD8F1 鼠乳腺肿瘤系统中 5-氟尿嘧啶代谢的影响。
Pharm Res. 1984 Mar;1(2):69-75. doi: 10.1023/A:1016351330832.
2
Applications of magnetic resonance in model systems: cancer therapeutics.磁共振在模型系统中的应用：癌症治疗学
Neoplasia. 2000 Jan-Apr;2(1-2):152-65. doi: 10.1038/sj.neo.7900078.
3
Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors.嘌呤和嘧啶合成抑制剂免疫抑制作用的体外比较研究。
Transplant Proc. 1993 Feb;25(1 Pt 1):781-3.
4
Modulation of 5-FU metabolism in human MCF-7 breast carcinoma cells.人MCF-7乳腺癌细胞中5-氟尿嘧啶代谢的调节
Cancer Chemother Pharmacol. 1982;8(1):87-91. doi: 10.1007/BF00292877.
5
Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation.通过代谢调节增加5-氟尿嘧啶掺入RNA来提高其抗肿瘤活性。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4966-70. doi: 10.1073/pnas.77.8.4966.
6
Phase-I trial of combination therapy with continuous-infusion MMPR and continuous-infusion 5-FU.
Cancer Chemother Pharmacol. 1984;13(2):136-8. doi: 10.1007/BF00257131.
7
Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites.尿苷诱导的小鼠和大鼠体温过低与血浆及组织中尿苷及其代谢产物水平的关系
Cancer Chemother Pharmacol. 1987;20(2):101-8. doi: 10.1007/BF00253962.
8
Effects of ciprofloxacin on eucaryotic pyrimidine nucleotide biosynthesis and cell growth.环丙沙星对真核嘧啶核苷酸生物合成及细胞生长的影响。
Antimicrob Agents Chemother. 1987 May;31(5):774-9. doi: 10.1128/AAC.31.5.774.
9
Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis.脱氧胞苷对人白血病细胞体外对从头嘧啶生物合成抑制剂反应的影响。
Cancer Chemother Pharmacol. 1987;19(3):226-32. doi: 10.1007/BF00252977.
10
Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).DUP-785（NSC 368390）对嘧啶从头合成的抑制作用。
Invest New Drugs. 1987;5(3):235-44. doi: 10.1007/BF00175293.