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Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase.

作者信息

Johnson R K, Swyryd E A, Stark G R

出版信息

Cancer Res. 1978 Feb;38(2):371-8.

PMID:620408
Abstract
摘要

相似文献

1
Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase.N-(膦酰基乙酰基)-L-天冬氨酸对小鼠肿瘤及正常组织的体内外作用以及敏感性与增殖速率和天冬氨酸转氨甲酰酶水平的关系
Cancer Res. 1978 Feb;38(2):371-8.
2
Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase.天冬氨酸转氨甲酰酶的过渡态抑制剂N-(膦酰乙酰基)-L-天冬氨酸的抗肿瘤活性
Cancer Res. 1976 Aug;36(8):2720-5.
3
Mechanisms of sensitivity or resistance of murine tumors to N-(phosphonacetyl)-L-aspartate (PALA).小鼠肿瘤对N-(膦酰乙酰基)-L-天冬氨酸(PALA)敏感或耐药的机制。
Cancer Treat Rep. 1979 Aug;63(8):1291-302.
4
Collateral sensitivity to N-(phosphonacetyl)-L-aspartic acid in a line of P388 leukemia cells selected for resistance to L-(alpha S, 5S)-alpha-amino-3- chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).对N-(膦酰基乙酰基)-L-天冬氨酸的 collateral 敏感性在一株对L-(αS,5S)-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸(阿西维辛)产生抗性的P388白血病细胞系中。 (注:“collateral”这里可能是专业术语“旁系的”之类意思,具体准确意思需结合专业知识进一步确定)
Cancer Res. 1983 Apr;43(4):1598-601.
5
Flux through the de novo pyrimidine pathway in vivo. Effect of N-phosphonacetyl-L-aspartate, a potent inhibitor of aspartate transcarbamylase.体内从头嘧啶途径的通量。天冬氨酸转氨甲酰酶的强效抑制剂N-膦酰乙酰-L-天冬氨酸的作用。
J Biol Chem. 1983 Nov 25;258(22):13564-9.
6
Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate.N-(膦酰乙酰基)-L-天冬氨酸对嘧啶合成的选择性抑制及核苷酸库的耗竭
Cancer Res. 1979 Aug;39(8):3089-94.
7
Phase I study of N-(phosphonacetyl)-L-aspartic acid (PALA).N-(膦酰基乙酰基)-L-天冬氨酸(PALA)的I期研究。
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1909-12.
8
Therapeutic effects of acivicin and N-(phosphonacetyl)-L-aspartic acid in a biochemically designed trial against a N-(phosphonacetyl)-L-aspartic acid-resistant variant of the Lewis lung carcinoma.在一项针对Lewis肺癌的N-(膦酰乙酰基)-L-天冬氨酸耐药变体的生化设计试验中阿西维辛和N-(膦酰乙酰基)-L-天冬氨酸的治疗效果
Cancer Res. 1981 Mar;41(3):905-9.
9
Serum uridine levels in patients receiving N-(phosphonacetyl)-L-aspartate.接受 N-(膦酰基乙酰基)-L-天冬氨酸治疗的患者的血清尿苷水平。
Cancer Res. 1980 Aug;40(8 Pt 1):2938-40.
10
N-(Phosphonacetyl)-L-aspartate (PALA): current status.
Recent Results Cancer Res. 1980;74:72-7. doi: 10.1007/978-3-642-81488-4_10.

引用本文的文献

1
Detoxification of N-(phosphonoacetyl)-L-aspartate by carrot cells in suspension culture.悬浮培养的胡萝卜细胞对 N-(膦酰乙酰基)-L-天冬氨酸的解毒作用。
Planta. 1985 Nov;166(3):401-6. doi: 10.1007/BF00401179.
2
Design, synthesis, and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase.新型大肠杆菌天冬氨酸转氨甲酰酶抑制剂的设计、合成及生物活性
Bioorg Med Chem Lett. 2007 Apr 1;17(7):2086-90. doi: 10.1016/j.bmcl.2006.12.050. Epub 2006 Dec 21.
3
Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation.
通过代谢调节增加5-氟尿嘧啶掺入RNA来提高其抗肿瘤活性。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4966-70. doi: 10.1073/pnas.77.8.4966.
4
Phase I trial of combination therapy of cancer with N-phosphonacetyl-L-aspartic acid and dipyridamole.N-膦酰乙酰-L-天冬氨酸与双嘧达莫联合治疗癌症的I期试验
Cancer Chemother Pharmacol. 1987;19(1):80-3. doi: 10.1007/BF00296262.
5
Mechanism-based model for tumor drug resistance.基于机制的肿瘤耐药模型。
Cancer Chemother Pharmacol. 1992;30(5):355-9. doi: 10.1007/BF00689962.
6
Hematologic and histopathologic evaluation of N-(phosphonacetyl)-L-aspartate (PALA) in mice.N-(膦酰基乙酰基)-L-天冬氨酸(PALA)在小鼠中的血液学和组织病理学评估
Cancer Chemother Pharmacol. 1979;2(3):183-7. doi: 10.1007/BF00258293.
7
m-AMSA and PALA: two new agents in cancer chemotherapy.m-AMSA和PALA:癌症化疗中的两种新药物。
Cancer Chemother Pharmacol. 1979;3(3):135-41. doi: 10.1007/BF00262414.