关于参与尿苷二磷酸-N-乙酰胞壁酰五肽合成的大肠杆菌酶的研究。
Studies on Escherichia coli enzymes involved in the synthesis of uridine diphosphate-N-acetyl-muramyl-pentapeptide.
作者信息
Lugtenberg E J
出版信息
J Bacteriol. 1972 Apr;110(1):26-34. doi: 10.1128/jb.110.1.26-34.1972.
Abstract
The specific activities of l-alanine:d-alanine racemase, d-alanine:d-alanine ligase, and the l-alanine, d-glutamic acid, meso-diaminopimelic acid, and d-alanyl-d-alanine adding enzymes were followed during growth of Escherichia coli. The specific activities were nearly independent of the growth phase. d-Alanine:d-alanine ligase was inhibited by d-alanyl-d-alanine, d-cycloserine, glycine, and glycyl-glycine. l-Alanine:d-alanine racemase was found to be sensitive to d-cycloserine, glycine, and glycyl-glycine. The l-alanine adding enzyme was inhibited by glycine and glycyl-glycine.
摘要
在大肠杆菌生长过程中，对L-丙氨酸：D-丙氨酸消旋酶、D-丙氨酸：D-丙氨酸连接酶以及L-丙氨酸、D-谷氨酸、内消旋二氨基庚二酸和D-丙氨酰-D-丙氨酸添加酶的比活性进行了跟踪。这些比活性几乎与生长阶段无关。D-丙氨酸：D-丙氨酸连接酶受到D-丙氨酰-D-丙氨酸、D-环丝氨酸、甘氨酸和甘氨酰甘氨酸的抑制。发现L-丙氨酸：D-丙氨酸消旋酶对D-环丝氨酸、甘氨酸和甘氨酰甘氨酸敏感。L-丙氨酸添加酶受到甘氨酸和甘氨酰甘氨酸的抑制。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
3
NUCLEOTIDE ACCUMULATION INDUCED IN STAPHYLOCOCCUS AUREUS BY GLYCINE.甘氨酸诱导金黄色葡萄球菌中的核苷酸积累。
J Bacteriol. 1965 Apr;89(4):1124-7. doi: 10.1128/jb.89.4.1124-1127.1965.
4
BIOCHEMICAL EFFECTS OF NOVOBIOCIN ON STAPHYLOCOCCUS AUREUS.新生霉素对金黄色葡萄球菌的生化作用
J Bacteriol. 1965 Apr;89(4):1117-23. doi: 10.1128/jb.89.4.1117-1123.1965.
5
THE ENZYMATIC SYNTHESIS OF D-ALANYL-D-ALANINE. 3. ON THE INHIBITION OF D-ALANYL-D-ALANINE SYNTHETASE BY THE ANTIBIOTIC D-CYCLOSERINE.D-丙氨酰-D-丙氨酸的酶促合成。3. 抗生素D-环丝氨酸对D-丙氨酰-D-丙氨酸合成酶的抑制作用
Biochemistry. 1964 Apr;3:471-80. doi: 10.1021/bi00892a001.
6
The enzymatic addition of D-alanyl-D-alanine to a uridine nucleotide-peptide.将D-丙氨酰-D-丙氨酸酶促添加到尿苷核苷酸-肽上。
J Biol Chem. 1962 May;237:1601-4.
7
Reversal of the growth inhibitory action of glycine and glycylglycine by alanylalanine in Mycobacterium smegmatis.丙氨酰丙氨酸对耻垢分枝杆菌中甘氨酸和甘氨酰甘氨酸生长抑制作用的逆转
Biochim Biophys Acta. 1969 Jul 30;184(2):460-3. doi: 10.1016/0304-4165(69)90051-8.
8
Coenzyme content of purified alanine racemase from Pseudomonas.来自假单胞菌的纯化丙氨酸消旋酶的辅酶含量。
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9
Selective inhibition of enzymes utilizing alanine in the biosynthesis of peptidoglycan.在肽聚糖生物合成中对利用丙氨酸的酶的选择性抑制。
Antimicrob Agents Chemother (Bethesda). 1967;7:304-13.
10
Effects of penicillin and glycine on cell wall glycopeptides of the two varieties of Vibrio fetus.青霉素和甘氨酸对胎儿弧菌两个变种细胞壁糖肽的影响。
J Bacteriol. 1968 Dec;96(6):1889-94. doi: 10.1128/jb.96.6.1889-1894.1968.
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