Southwick F S, Carr H S, Carden G A, D'Alisa R M, Rosenkranz H S
J Bacteriol. 1972 Apr;110(1):439-41. doi: 10.1128/jb.110.1.439-441.1972.
Exposure of Escherichia coli to critical acridine orange (AO) concentrations did not result in loss of viability. However, the deoxyribonucleic acid (DNA) of cells exposed to such agents was rapidly degraded and repolymerized. On the other hand, a bacterium deficient in DNA repair (pol A(1) (-), lacking DNA polymerase) was sensitive to the action of AO. The DNA of such cells was also degraded but it was not repaired.
将大肠杆菌暴露于临界浓度的吖啶橙（AO）中并不会导致其活力丧失。然而，暴露于此类试剂的细胞的脱氧核糖核酸（DNA）会迅速降解并重新聚合。另一方面，一种缺乏DNA修复能力（pol A(1) (-)，缺乏DNA聚合酶）的细菌对AO的作用敏感。此类细胞的DNA也会降解，但无法修复。
