Rosenkranz H S, Carr H S
Antimicrob Agents Chemother. 1972 Nov;2(5):367-72. doi: 10.1128/AAC.2.5.367.
Even though the addition of silver sulfadiazine (AgSu) to purified deoxyribonucleic acid (DNA) results in the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. AgSu blocked macromolecular syntheses in treated bacteria, DNA synthesis being slightly more sensitive to this inhibitory action. The ribosomes, ribonucleic acid, and DNA isolated from treated cells were normal qualitatively. Bacteria deficient in DNA polymerase were not more sensitive than their parent strain to the lethal action of AgSu. Radioactive AgSu was localized mainly in the cytoplasmic membrane fraction of treated cells.
尽管将磺胺嘧啶银（AgSu）添加到纯化的脱氧核糖核酸（DNA）中会导致形成AgSu-DNA复合物，但在用AgSu处理的细菌中未检测到此类复合物。AgSu阻断了处理过的细菌中的大分子合成，DNA合成对这种抑制作用稍更敏感。从处理过的细胞中分离出的核糖体、核糖核酸和DNA在质量上是正常的。缺乏DNA聚合酶的细菌对AgSu的致死作用并不比其亲本菌株更敏感。放射性AgSu主要定位于处理过的细胞的细胞质膜部分。
