米拉西尔D：对缺乏脱氧核糖核酸聚合酶的大肠杆菌的抑制作用。
Miracil D: inhibition of deoxyribonucleic acid polymerase-deficient Escherichia coli.
作者信息
Rosenkranz H S
出版信息
Antimicrob Agents Chemother. 1973 Apr;3(4):530-1. doi: 10.1128/AAC.3.4.530.
Abstract
Miracil D preferentially inhibited the growth of a deoxyribonucleic acid (DNA) polymerase-deficient Escherichia coli strain. This is taken to indicate that miracil D is capable of altering the DNA of living cells and that it may thereby be a potential mutagen and carcinogen.
摘要
米拉西尔D优先抑制一种缺乏脱氧核糖核酸（DNA）聚合酶的大肠杆菌菌株的生长。这被认为表明米拉西尔D能够改变活细胞的DNA，因此它可能是一种潜在的诱变剂和致癌物。
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本文引用的文献
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PHENETHYL ALCOHOL. I. EFFECT ON MACROMOLECULAR SYNTHESIS OF ESCHERICHIA COLI.苯乙醇。一、对大肠杆菌大分子合成的影响。
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Hycanthone: a frameshift mutagen.海蒽酮：一种移码诱变剂。
Science. 1971 Jun 4;172(3987):1058-60. doi: 10.1126/science.172.3987.1058.
3
Structure-activity studies on the mechanism of action of miracil D.关于米腊西尔D作用机制的构效关系研究。
Cancer Res. 1968 Mar;28(3):601-7.
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Unusual growth properties of a bacterial strain lacking DNA polymerase.一种缺乏DNA聚合酶的细菌菌株的异常生长特性。
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Rapid detection of mutagens and carcinogens.诱变剂和致癌物的快速检测
Cancer Res. 1971 Jul;31(7):970-3.
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Repair of damage induced by ultraviolet light in DNA polymerase-defective Escherichia coli cells.DNA聚合酶缺陷型大肠杆菌细胞中紫外线诱导损伤的修复
J Mol Biol. 1971 Jun 14;58(2):623-30. doi: 10.1016/0022-2836(71)90376-7.
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DNA polymerase required for rapid repair of x-ray--induced DNA strand breaks in vivo.体内X射线诱导的DNA链断裂快速修复所需的DNA聚合酶。
Science. 1971 May 21;172(3985):851-4. doi: 10.1126/science.172.3985.851.
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Tumorigenicity of acridine orange.吖啶橙的致瘤性。
Br J Cancer. 1969 Sep;23(3):587-90. doi: 10.1038/bjc.1969.72.
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Isolation of an E. coli strain with a mutation affecting DNA polymerase.分离出一株具有影响DNA聚合酶突变的大肠杆菌菌株。
Nature. 1969 Dec 20;224(5225):1164-6. doi: 10.1038/2241164a0.
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J Bacteriol. 1972 Apr;110(1):439-41. doi: 10.1128/jb.110.1.439-441.1972.
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