克氏锥虫中与烟酰胺腺嘌呤二核苷酸（NAD）相关的谷氨酸脱氢酶
NAD-linked glutamate dehydrogenase in Trypanosoma cruzi.
作者信息
Cazzulo J J, de Cazzulo B M, Higa A I, Segura E L
机构信息
Centro de Estudios Fotosintéticos y Bioquímicos, Rosario, Argentina.
出版信息
Comp Biochem Physiol B. 1979;64(1):129-31. doi: 10.1016/0305-0491(79)90197-4.
PMID:45532
Abstract
- Epimastigotes of Trypanosoma cruzi, Tulahuén strain, contained a NAD-linked glutamate dehydrogenase (EC 1.4.1.3), in addition to the already known NADP-linked enzyme enzyme (EC 1.4.1.4). 2. The partially purified NAD-linked enzyme had a higher molecular weight and was much more labile than the NADP-linked enzyme, and was inhibited by purine nucleotides. 3. These results further emphasize the difference in glutamate metabolism between the parasite and its mammalian host.
摘要
- 克氏锥虫图拉韦恩株的前鞭毛体，除了已为人知的与NADP相关的酶（EC 1.4.1.4）外，还含有一种与NAD相关的谷氨酸脱氢酶（EC 1.4.1.3）。2. 部分纯化的与NAD相关的酶分子量更高，比与NADP相关的酶更不稳定，且受到嘌呤核苷酸的抑制。3. 这些结果进一步强调了该寄生虫与其哺乳动物宿主在谷氨酸代谢方面的差异。
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