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从异种抗淋巴细胞血清的作用中恢复的方式。I. 免疫反应的恢复。

Mode of recovery from the effects of heterologous anti-lymphocyte serum. I. Recovery of the immune response.

作者信息

Jeejeebhoy H F, Singla O

出版信息

Immunology. 1972 May;22(5):789-99.

Abstract

Free immunosuppressive antibody is frequently demonstrable in the sera of mice for some days after the completion of a course of ALS. The potency of the immunosuppressive material which is present and the duration for which it remains in the circulation varies according to the ALS used. These two factors appear to be of major importance in determining the rate at which immunological competence is restored to an ALS-treated animal. Recovery is retarded by the presence of free immunosuppressive antibody in the circulation and the degree of retardation is directly proportional to the potency of the material present and the duration for which it remains in the circulation.

摘要

在完成抗淋巴细胞血清(ALS)疗程后的数天内,小鼠血清中常常能检测到游离的免疫抑制抗体。所存在的免疫抑制物质的效力及其在循环系统中存留的时间会因所用的抗淋巴细胞血清而异。这两个因素在决定接受抗淋巴细胞血清治疗的动物免疫能力恢复的速率方面似乎至关重要。循环系统中游离免疫抑制抗体的存在会延缓恢复,且延缓程度与所存在物质的效力及其在循环系统中存留的时间成正比。

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