一些影响抗淋巴细胞抗体抑制体液抗体形成能力的因素。
Some factors influencing the ability of anti-lymphocytic antibody to suppress humoral antibody formation.
作者信息
James K
出版信息
Clin Exp Immunol. 1967 Nov;2(6):685-90.
Abstract
The pre-treatment of hooded female rats with horse anti-rat lymphocyte IgG suppresses and/or delays their primary humoral antibody response to alum precipitated bovine serum albumin. Treatment with anti-lymphocytic antibody commencing 4 hr after the administration of antigen proved ineffective. The non-cytotoxic F(ab') fragments prepared from horse and rabbit anti-rat lymphocyte IgG both failed to inhibit the primary response to alum precipitated bovine serum albumin when administered prior to antigen. The significance of these results in relationship to the immunosuppressive properties of anti-lymphocytic antibody is discussed.
摘要
用马抗大鼠淋巴细胞IgG对雌性有帽大鼠进行预处理，可抑制和/或延迟它们对明矾沉淀牛血清白蛋白的初次体液抗体反应。在给予抗原后4小时开始用抗淋巴细胞抗体治疗无效。从马和兔抗大鼠淋巴细胞IgG制备的无细胞毒性的F(ab')片段，在抗原之前给药时，均未能抑制对明矾沉淀牛血清白蛋白的初次反应。本文讨论了这些结果与抗淋巴细胞抗体免疫抑制特性的关系。
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Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds.通过二硫键还原从二价兔抗体分子中分离单价片段。
Arch Biochem Biophys. 1960 Aug;89:230-44. doi: 10.1016/0003-9861(60)90049-7.
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J Infect Dis. 1958 Nov-Dec;103(3):239-62. doi: 10.1093/infdis/103.3.239.
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