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Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 5. Clinical comparison of difenoxine and diphenoxylate in volunteers and in patients with chronic diarrhea. Double-blind cross-over assessments.

作者信息

Rubens R, Verhaegen H, Brugmans J, Schuermans V

出版信息

Arzneimittelforschung. 1972 Mar;22(3):526-9.

PMID:4556767
Abstract
摘要

相似文献

1
Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 5. Clinical comparison of difenoxine and diphenoxylate in volunteers and in patients with chronic diarrhea. Double-blind cross-over assessments.
Arzneimittelforschung. 1972 Mar;22(3):526-9.
2
Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 2. Difneozine, a potent, orally active and safe antidiarrheal agent in rats.地芬诺辛(R 15403),是地芬诺酯(R 1132)的活性代谢产物。2. 地芬诺辛,一种对大鼠强效、口服活性且安全的止泻剂。
Arzneimittelforschung. 1972 Mar;22(3):516-8.
3
A comparative double-blind study of two antidiarrhoeals, difenoxine and loperamide.两种止泻药——地芬诺辛和洛哌丁胺的双盲对照研究。
Tijdschr Gastroenterol. 1972;15(5):337-42.
4
Diphenoxylate in diarrhoea and vomiting.地芬诺酯用于腹泻和呕吐。
Practitioner. 1972 Jul;209(249):99-102.
5
A double blind crossover comparison of loperamide with diphenoxylate in the symptomatic treatment of chronic diarrhea.洛哌丁胺与地芬诺酯对症治疗慢性腹泻的双盲交叉比较。
Gastroenterology. 1976 Jun;70(6):1030-4.
6
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 8: Clinical investigation. Use of a flexible dosage schedule in a double-blind comparison of loperamide with diphenoxylate in 614 patients suffering from acute diarrhea.洛哌丁胺(R 18 553),一种新型止泻药。第八部分:临床研究。在614例急性腹泻患者中,采用灵活剂量方案对洛哌丁胺与地芬诺酯进行双盲比较。
Arzneimittelforschung. 1974 Oct;24(10):1660-5.
7
[Clinical effectiveness of difenoxine in patients with acute and chronic diarrhea].地芬诺酯对急慢性腹泻患者的临床疗效
Boll Chim Farm. 1983 Dec;122(12):64S-68S.
8
[The constipating effect of diphenoxylate (Retardin) in ulcerative colitis. A double-blind controlled study].[地芬诺酯(复方苯乙哌啶)对溃疡性结肠炎的致便秘作用。一项双盲对照研究]
Ugeskr Laeger. 1975 Apr 28;137(18):985-8.
9
Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 6. Absorption, excretion and metabolism in man.
Arzneimittelforschung. 1972 Mar;22(3):529-31.
10
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 7: Clinical investigation. Efficacy and safety of loperamide in patients with severe chronic diarrhea.洛哌丁胺(R 18 553),一种新型止泻药。第7部分:临床研究。洛哌丁胺治疗严重慢性腹泻患者的疗效和安全性。
Arzneimittelforschung. 1974 Oct;24(10):1657-60.

引用本文的文献

1
Pharmacologically active metabolites of drugs and other foreign compounds. Clinical, pharmacological, therapeutic and toxicological considerations.药物及其他外来化合物的药理活性代谢产物。临床、药理、治疗及毒理学考量。
Drugs. 1982 Dec;24(6):519-42. doi: 10.2165/00003495-198224060-00003.
2
Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.药理活性药物代谢物:治疗及毒性活性、人体血浆及尿液数据、肾衰竭时的蓄积情况
Clin Pharmacokinet. 1976 Nov-Dec;1(6):426-43. doi: 10.2165/00003088-197601060-00003.