迷走神经干切断术对胃酸和胃蛋白酶的影响：人体对一种胆碱能药物的反应。
Effect of truncal vagotomy on acid and pepsin: response to a cholinergic drug in man.
作者信息
Cowley D J
出版信息
Gut. 1972 Feb;13(2):99-102. doi: 10.1136/gut.13.2.99.
The gastric output of acid and pepsin in response to two doses of the cholinergic drug carbachol was measured before and two months after complete truncal vagotomy and pyloroplasty in eight patients with duodenal ulcer. After vagotomy the basal output of acid and pepsin was reduced and there was no stimulation of secretion by a subthreshold dose of carbachol (0.5 units/kg) nor was there an increase in the response to a submaximal dose of carbachol (2.0 units/kg).Cannon's criteria for denervation supersensitivity of an organ were not obeyed with regard to acid or pepsin secretion.
在8例十二指肠溃疡患者中，测量了在完全性迷走神经切断术和幽门成形术前以及术后两个月，给予两剂胆碱能药物卡巴胆碱后胃酸和胃蛋白酶的分泌量。迷走神经切断术后，胃酸和胃蛋白酶的基础分泌量减少，阈下剂量的卡巴胆碱（0.5单位/千克）不能刺激分泌，对次最大剂量的卡巴胆碱（2.0单位/千克）的反应也没有增加。在胃酸或胃蛋白酶分泌方面，未遵循坎农关于器官去神经超敏反应的标准。
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