Roland M, Berstad A, Liavåg I
Scand J Gastroenterol. 1975;10(4):363-7.
Gastric secretion was stimulated by intravenous infusion of 15 mug/kg/hr of pentagastrin before and 10 and 90 days after proximal gastric vagotomy in 16 duodenal ulcer patients. Postoperatively 15 ug/kg/hr of pentagastrin was also given in combination with 2 mug/kg/hr of carbacholine. Mean acid output in response to pentagastrin alone was reduced by 48 and 64 per cent at 10 and 90 days after the vagotomy, respectively. Mean pentagastrin-stimulated acid output and volume of gastric juice was significantly higher at 10 days than at 90 days after the operation. Mean pepsin output decreased also, but the decrease was not statistically significant. There was no significant effect of carbacholine on pentagastrin-stimulated acid output either at 10 or 90 days. Carbacholine increased pentagastrin-stimulated volume of gastric juice significantly at 10 but not 90 days postoperatively. The effect of carbacholine on pentagastrin-stimulated pepsin output was significant both 10 and 90 days after the vagotomy. Pepsin output in response to pentagastrin plus carbacholine 10 days after the operation was not significantly different from preoperative values. At 10 days postoperatively the increase in pentagastrin-stimulated volume of gastric juice by carbacholine was significantly greater than at 90 days. The corresponding differences of acid and pepsin outputs were not significant.
对16例十二指肠溃疡患者在近端胃迷走神经切断术前、术后10天和90天，通过静脉输注五肽胃泌素15微克/千克/小时来刺激胃液分泌。术后，五肽胃泌素15微克/千克/小时还与卡巴胆碱2微克/千克/小时联合使用。单独使用五肽胃泌素时，迷走神经切断术后10天和90天的平均酸分泌量分别降低了48%和64%。术后10天五肽胃泌素刺激的平均酸分泌量和胃液量显著高于90天。平均胃蛋白酶分泌量也有所下降，但下降无统计学意义。卡巴胆碱在术后10天或90天对五肽胃泌素刺激的酸分泌量均无显著影响。卡巴胆碱在术后10天显著增加了五肽胃泌素刺激的胃液量，但90天时未增加。迷走神经切断术后10天和90天，卡巴胆碱对五肽胃泌素刺激的胃蛋白酶分泌量的影响均显著。术后10天，五肽胃泌素加卡巴胆碱刺激的胃蛋白酶分泌量与术前值无显著差异。术后10天，卡巴胆碱增加五肽胃泌素刺激的胃液量的幅度显著大于90天。酸分泌量和胃蛋白酶分泌量的相应差异不显著。
