噬菌体T7感染后蛋白质合成的负调控
Negative control of protein synthesis after infection with bacteriophage T7.
作者信息
Schweiger M, Herrlich P, Scherzinger E, Rahmsdorf H J
出版信息
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2203-7. doi: 10.1073/pnas.69.8.2203.
Abstract
T7 phage induces two negative control mechanisms of protein synthesis: (a) Host-gene expression is repressed by a "T7 repressor," and (b) early T7 protein synthesis is inhibited by a late phage protein.(a) The repressor for host enzyme synthesis is an early T7 protein. Its gene is none of the known early genes; it is located promotor-proximal to gene 1. The repressor function of this protein can be demonstrated by DNA-dependent enzyme synthesis in vitro.(b) Expression of early phage gene is depressed by a late phage protein or by T7 RNA polymerase. Control takes place on the level of transcription.
摘要
T7噬菌体诱导蛋白质合成的两种负调控机制：(a) 宿主基因表达被一种“T7阻遏物”所抑制，(b) 早期T7蛋白质合成被一种晚期噬菌体蛋白质所抑制。(a) 宿主酶合成的阻遏物是一种早期T7蛋白质。其基因不是已知的早期基因；它位于基因1的启动子近端。这种蛋白质的阻遏功能可通过体外依赖DNA的酶合成来证明。(b) 早期噬菌体基因的表达被一种晚期噬菌体蛋白质或T7 RNA聚合酶所抑制。调控发生在转录水平。
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