Tseng L, Dramusic V, Gurpide E
Contraception. 1979 Mar;19(3):247-52. doi: 10.1016/0010-7824(79)90019-2.
In order to determine whether inhibition of the endometrial estradiol-17 beta-dehydrogenase activity by Cu++ could be one of the factors accounting for the enhanced contraceptive efficacy of copper intrauterine devices (Cu-IUD), the activity of the enzyme was measured in endometrial biopsies from women wearing this device. The levels of enzymatic activity found in these specimens were within the range of controls (women without IUD), e.g. 0.1--0.8 and 7--27 nmol E1 formed/mg protein/h in the follicular and luteal phases of the menstrual cycle, respectively. It is concluded that Cu-IUD does not modify significantly either the activity of endometrial-17 beta-dehydrogenase, an enzyme known to regulate the tissular concentration of estradiol, or its response to the inductive effect of progesterone.
为了确定铜离子对子宫内膜雌二醇-17β-脱氢酶活性的抑制作用是否可能是铜宫内节育器（Cu-IUD）避孕效果增强的因素之一，对佩戴该装置的女性子宫内膜活检样本中的该酶活性进行了测定。这些样本中发现的酶活性水平在对照组（未佩戴宫内节育器的女性）范围内，例如在月经周期的卵泡期和黄体期，每毫克蛋白质每小时分别形成0.1--0.8和7--27 nmol的雌二醇。得出的结论是，Cu-IUD对子宫内膜-17β-脱氢酶（一种已知可调节组织中雌二醇浓度的酶）的活性或其对孕酮诱导作用的反应均无显著影响。
